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Viscera Characteristics of MSTN -Edited Heterozygous Pigs
Ist Teil von
Frontiers in genetics, 2022-03, Vol.13, p.764965-764965
Ort / Verlag
Switzerland: Frontiers Media S.A
Erscheinungsjahr
2022
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Myostatin (MSTN) is a protein that negatively regulates growth of skeletal muscle, and inactivation of MSTN improves the mass of skeletal muscle. Our previous work found that
pigs have higher muscle depth and lower fat depth compared to wild type without any developmental problems. Therefore,
-edited pigs are most likely to appear as heterozygotes in the potential future market, but the characteristics of organs in digestive and reproductive system of pigs with
gene editing remains unclear. Here, we investigated the histological of the organs in the digestive system and reproductive system in
gene heterozygotes at adult stages. The length of intestine was further compared between adult heterozygous and wild type pigs. We found no significant differences in histomorphology of organs, including heart, duodenum, jejunum, ileum, cecum, colon, testis, epididymis, ovaries, oviducts and uterus, between individuals from two genotypes. Moreover, there was no significant difference in the average length of intestine in adult pigs. Our data provide a reference for further clarifying the applications of
gene edited pigs.