Nature communications, 2018-07, Vol.9 (1), p.2724-13, Article 2724
2018
Details
- Autor(en) / Beteiligte
- Titel
- Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
- Ist Teil von
- Nature communications, 2018-07, Vol.9 (1), p.2724-13, Article 2724
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2018
- Link zum Volltext
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that CD103 CD39 tumor-infiltrating CD8 T cells (CD8 TIL) are enriched for tumor-reactive cells both in primary and metastatic tumors. This CD8 TIL subset is found across six different malignancies and displays an exhausted tissue-resident memory phenotype. CD103 CD39 CD8 TILs have a distinct T-cell receptor (TCR) repertoire, with T-cell clones expanded in the tumor but present at low frequencies in the periphery. CD103 CD39 CD8 TILs also efficiently kill autologous tumor cells in a MHC-class I-dependent manner. Finally, higher frequencies of CD103 CD39 CD8 TILs in patients with head and neck cancer are associated with better overall survival. Our data thus describe an approach for detecting tumor-reactive CD8 TILs that will help define mechanisms of existing immunotherapy treatments, and may lead to future adoptive T-cell cancer therapies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-018-05072-0Titel-ID: cdi_doaj_primary_oai_doaj_org_article_7f90edfb8d4e4077bb1febd57a7e1381
- Format
- –
- Schlagworte
- Adenocarcinoma of Lung - genetics, Adenocarcinoma of Lung - immunology, Adenocarcinoma of Lung - mortality, Adenocarcinoma of Lung - pathology, Antigens, CD - genetics, Antigens, CD - immunology, Apyrase - genetics, Apyrase - immunology, BASIC BIOLOGICAL SCIENCES, Cancer, Carcinoma, Squamous Cell - genetics, Carcinoma, Squamous Cell - immunology, Carcinoma, Squamous Cell - mortality, Carcinoma, Squamous Cell - pathology, CD103 antigen, CD8 antigen, CD8 Antigens - genetics, CD8 Antigens - immunology, CD8-Positive T-Lymphocytes - immunology, CD8-Positive T-Lymphocytes - pathology, Female, Head, Head & neck cancer, Head and neck cancer, Humans, Immunophenotyping, Immunotherapy, Integrin alpha Chains - genetics, Integrin alpha Chains - immunology, Lymphocytes, Lymphocytes T, Lymphocytes, Tumor-Infiltrating - immunology, Lymphocytes, Tumor-Infiltrating - pathology, Major histocompatibility complex, Male, Melanoma - genetics, Melanoma - immunology, Melanoma - mortality, Melanoma - pathology, Metastases, Ovarian Neoplasms - genetics, Ovarian Neoplasms - immunology, Ovarian Neoplasms - mortality, Ovarian Neoplasms - pathology, Patients, Phenotypes, Receptors, Antigen, T-Cell, alpha-beta - genetics, Receptors, Antigen, T-Cell, alpha-beta - immunology, Solid tumors, Squamous Cell Carcinoma of Head and Neck - genetics, Squamous Cell Carcinoma of Head and Neck - immunology, Squamous Cell Carcinoma of Head and Neck - mortality, Squamous Cell Carcinoma of Head and Neck - pathology, Survival Analysis, T cell receptors, Transcriptome, Tumor cells, Tumors