International journal of molecular sciences, 2017-09, Vol.18 (10), p.2052
2017
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- Autor(en) / Beteiligte
- Titel
- Anti-Photoaging Effect of Jeju Putgyul (Unripe Citrus) Extracts on Human Dermal Fibroblasts and Ultraviolet B-induced Hairless Mouse Skin
- Ist Teil von
- International journal of molecular sciences, 2017-09, Vol.18 (10), p.2052
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Ultraviolet (UV) radiation stimulates the expression of matrix metalloproteinases (MMPs) and inflammatory cytokines. These signaling pathways participate in the degradation of the extracellular matrix and induce inflammatory responses that lead to photoaging. This study evaluated the antioxidant activity and the effect on MMPs and procollagen of putgyul extract in vitro. The anti-photoaging activity of putgyul extracts was estimated in vivo using hairless mice (HR-1). The putgyul extracts reduced MMP-1 production and increased the content of procollagen type I carboxy-terminal peptide in human dermal fibroblasts. Ultravilot-B (UVB)-induced expression of inflammatory cytokines and MMPs was detected in mice, and putgyul extracts suppressed the expression. These results suggest that putgyul extract inhibits photoaging by inhibiting the expression of MMPs that degrade collagen and inhibiting cytokines that induce inflammatory responses. The mouse model also demonstrated that oral administration of putgyul extracts decreased wrinkle depth, epidermal thickness, collagen degradation, and trans-epidermal water loss, and increased β-glucosidase activity on UVB exposed skin. Putgyul extract protects against UVB-induced damage of skin and could be valuable in the prevention of photoaging.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms18102052Titel-ID: cdi_doaj_primary_oai_doaj_org_article_7f25ec5539d5493aaf90ed19327dbb00
- Format
- –
- Schlagworte
- Animals, anti-photoaging, Antioxidants, Antioxidants - pharmacology, Biomarkers, Citrus - chemistry, Citrus unshiu S.Marcov, Collagen, Collagen - metabolism, Cytokines, Cytokines - metabolism, Damage prevention, Epidermis - cytology, Extracellular matrix, Fibroblasts, Fibroblasts - drug effects, Fibroblasts - metabolism, Gene Expression Regulation - drug effects, Glucosidase, Hairless, hairless mice, human dermal fibroblasts, Humans, Inflammation, Inflammation Mediators - metabolism, Interstitial collagenase, Matrix metalloproteinase, Matrix metalloproteinases, Matrix Metalloproteinases - genetics, Matrix Metalloproteinases - metabolism, Mice, Mice, Hairless, Oral administration, Plant Extracts - pharmacology, Procollagen, Protective Agents - pharmacology, RNA, Messenger - genetics, RNA, Messenger - metabolism, Rodents, Skin, Skin Aging - drug effects, Skin Aging - genetics, Skin Aging - pathology, Skin Aging - radiation effects, Studies, Ultraviolet radiation, Ultraviolet Rays - adverse effects, Water loss