Details

Autor(en) / Beteiligte

• Wiedorn, Max O
• Oberthür, Dominik
• Bean, Richard
• Schubert, Robin
• Aepfelbacher, Martin
• Adriano, Luigi
• Allahgholi, Aschkan
• Al-Qudami, Nasser
• Andreasson, Jakob
• Aplin, Steve
• Awel, Salah
• Ayyer, Kartik
• Bajt, Saša
• Bari, Sadia
• Bielecki, Johan
• Botha, Sabine
• Boukhelef, Djelloul
• Brehm, Wolfgang
• Cheviakov, Igor
• Coleman, Matthew A
• Cruz-Mazo, Francisco
• Danilevski, Cyril
• Darmanin, Connie
• Dörner, Katerina
• Du, Yang
• Fangohr, Hans
• Fleckenstein, Holger
• Frank, Matthias
• Fromme, Petra
• Gevorkov, Yaroslav
• Giewekemeyer, Klaus
• Ginn, Helen Mary
• Graafsma, Heinz
• Graceffa, Rita
• Greiffenberg, Dominic
• Göttlicher, Peter
• Hauf, Steffen
• Holmes, Susannah
• Horke, Daniel A
• Hunter, Mark S
• Kaukher, Alexander
• Kim, Yoonhee
• Klyuev, Alexander
• Kobe, Bostjan
• Kuhn, Manuela
• Kupitz, Christopher
• Küpper, Jochen
• Laurus, Torsten
• Le Cong, Karoline
• Letrun, Romain
• Xavier, P Lourdu
• Maia, Luis
• Maia, Filipe R N C
• Metz, Markus
• Mezza, Davide
• Michelat, Thomas
• Mills, Grant
• Monteiro, Diana C F
• Morgan, Andrew
• Munke, Anna
• Münnich, Astrid
• Nette, Julia
• Nugent, Keith A
• Nuguid, Theresa
• Orville, Allen M
• Pandey, Suraj
• Pena, Gisel
• Villanueva-Perez, Pablo
• Poehlsen, Jennifer
• Previtali, Gianpietro
• Redecke, Lars
• Riekehr, Winnie Maria
• Round, Adam
• Safenreiter, Tatiana
• Sarrou, Iosifina
• Schmidt, Marius
• Schönherr, Robert
• Schulz, Joachim
• Seibert, M Marvin
• Seuring, Carolin
• Shelby, Megan L
• Shoeman, Robert L
• Silenzi, Alessandro
• Sztuk-Dambietz, Jola
• Szuba, Janusz
• Tolstikova, Aleksandra
• Trunk, Ulrich
• Vagovic, Patrik
• Ve, Thomas
• Weinhausen, Britta
• White, Thomas A
• Wrona, Krzysztof
• Xu, Chen
• Zatsepin, Nadia
• Zhang, Jiaguo
• Perbandt, Markus
• Mancuso, Adrian P
• Betzel, Christian
• Chapman, Henry
• Barty, Anton

Titel

Megahertz serial crystallography

Ist Teil von

• Nature communications, 2018-10, Vol.9 (1), p.4025-11, Article 4025

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a β-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.