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Osmunda japonica Extract Suppresses Pro-Inflammatory Cytokines by Downregulating NF-κB Activation in Periodontal Ligament Fibroblasts Infected with Oral Pathogenic Bacteria
Ist Teil von
International journal of molecular sciences, 2020-04, Vol.21 (7), p.2453
Ort / Verlag
Switzerland: MDPI AG
Erscheinungsjahr
2020
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Periodontal diseases are caused by bacterial infection and may progress to chronic dental disease; severe inflammation may result in bone loss. Therefore, it is necessary to prevent bacterial infection or control inflammation. Periodontal ligament fibroblasts (PDLFs) are responsible for the maintenance of tissue integrity and immune and inflammatory events in periodontal diseases. The formation of bacterial complexes by
and
is crucial in the pathogenesis of periodontal disease.
is a facultative anaerobic species, considered to be a key mediator of dental plaque maturation and aggregation of other oral bacteria.
is an obligate anaerobic species that induces gingival inflammation by secreting virulence factors. In this study, we investigated whether
extract exerted anti-inflammatory effects in primary PDLFs stimulated by oral pathogens. PDLFs were stimulated with
or
. We showed that pro-inflammatory cytokine (IL-6 and IL-8) expression was induced by LPS or bacterial infection but decreased by treatment with
extract following bacterial infection. We found that the activation of NF-κB, a transcription factor for pro-inflammatory cytokines, was modulated by
extract. Thus,
extract has immunomodulatory activity that can be harnessed to control inflammation.