Details

Autor(en) / Beteiligte

• Cui, Jiuwei
• Yang, Guozi
• Pan, Zhenyu
• Zhao, Yuguang
• Liang, Xinyue
• Li, Wei
• Cai, Lu

Titel

Hormetic Response to Low-Dose Radiation: Focus on the Immune System and Its Clinical Implications

Ist Teil von

• International journal of molecular sciences, 2017-01, Vol.18 (2), p.280-280

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• The interrelationship between ionizing radiation and the immune system is complex, multifactorial, and dependent on radiation dose/quality and immune cell type. High-dose radiation usually results in immune suppression. On the contrary, low-dose radiation (LDR) modulates a variety of immune responses that have exhibited the properties of immune hormesis. Although the underlying molecular mechanism is not fully understood yet, LDR has been used clinically for the treatment of autoimmune diseases and malignant tumors. These advancements in preclinical and clinical studies suggest that LDR-mediated immune modulation is a well-orchestrated phenomenon with clinical potential. We summarize recent developments in the understanding of LDR-mediated immune modulation, with an emphasis on its potential clinical applications.