Details

Autor(en) / Beteiligte

• Luo, Bingling
• Wang, Jiankang
• Li, Xiaobing
• Lu, Wenhua
• Yang, Jing
• Hu, Yumin
• Huang, Peng
• Wen, Shijun

Titel

New Mild and Simple Approach to Isothiocyanates: A Class of Potent Anticancer Agents

Ist Teil von

• Molecules (Basel, Switzerland), 2017-06, Vol.22 (6), p.773

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Electronic Journals Library - Freely accessible e-journals

Beschreibungen/Notizen

• In our current work, acetyl chloride-mediated synthesis of phenethyl isothiocyanate (PEITC) derivatives proves to be convenient and provides the expected products at good to excellent yields. Biological evaluation and structure-activity relationship analysis found that the novel compound showed the best anticancer activity against human cancer cell line Panc1 and HGC27 compared with PEITC. Compounds and induced more apoptosis in pancreatic cancer cells but less toxicity in non-cancer cells. Further biological study demonstrated that substantially increased intracellular reactive oxygen species (ROS) and depleted glutathione (GSH), leading to an oxidative stress to kill cancer cell.