Details

Autor(en) / Beteiligte

• Pérez-Lara, Jocelyn C
• Espinosa, Enrique
• Santos-Argumedo, Leopoldo
• Romero-Ramírez, Héctor
• López-Herrera, Gabriela
• García-García, Fabio
• Sandoval-Montes, Claudia
• Ortiz-Navarrete, Vianney
• Flores-Muñoz, Mónica
• Rodríguez-Alba, Juan C

Titel

CD38 Correlates with an Immunosuppressive Treg Phenotype in Lupus-Prone Mice

Ist Teil von

• International journal of molecular sciences, 2021-11, Vol.22 (21), p.11977

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2021

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• CD38 is a transmembrane glycoprotein expressed by T-cells. It has been reported that patients with systemic lupus erythematosus (SLE) showed increased CD38 CD25 T-cells correlating with immune activation and clinical signs. Contrariwise, CD38 deficiency in murine models has shown enhanced autoimmunity development. Recent studies have suggested that CD38 regulatory T-cells are more suppressive than CD38 regulatory T-cells. Thus, we have suggested that CD38 overexpression in SLE patients could play a role in regulating immune activation cells instead of enhancing it. This study found a correlation between CD38 with FoxP3 expression and immunosuppressive molecules (CD69, IL-10, CTLA-4, and PD-1) in T-cells from lupus-prone mice (B6.MRL-Fas /J). Additionally, B6.MRL-Fas /J mice showed a decreased proportion of CD38 Treg cells regarding wild-type mice (WT). Furthermore, Regulatory T-Cells (Treg cells) from mice showed impairment in expressing immunosuppressive molecules and proliferation after stimulation through the T-cell receptor (TCR). Finally, we demonstrated an increased ratio of IFN-γ/IL-10 secretion in splenocytes stimulated with anti-CD3 compared with the WT. Altogether, our data suggest that CD38 represents an element in maintaining activated and proliferative Treg cells. Consequently, CD38 could have a crucial role in immune tolerance, preventing SLE development through Treg cells.