Details

Autor(en) / Beteiligte

• Geva, Sharon
• Schneider, Letitia M.
• Roberts, Sophie
• Khan, Shamima
• Gajardo-Vidal, Andrea
• Lorca-Puls, Diego L.
• team, PLORAS
• Hope, Thomas M.H.
• Green, David W.
• Price, Cathy J.

Titel

Right cerebral motor areas that support accurate speech production following damage to cerebellar speech areas

Ist Teil von

• NeuroImage clinical, 2021-01, Vol.32, p.102820-102820, Article 102820

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• [Display omitted] •Participants with damage to cerebellar speech regions were studied with fMRI.•At the time of test, their speech production was accurate and precise.•Their speech production activation was enhanced in right hemisphere motor regions.•We provide hypotheses for targeting future fMRI and brain stimulation studies. Specific regions of the cerebellum are activated when neurologically intact adults speak, and cerebellar damage can impair speech production early after stroke, but how the brain supports accurate speech production years after cerebellar damage remains unknown. We investigated this in patients with cerebellar lesions affecting regions that are normally recruited during speech production. Functional MRI activation in these patients, measured during various single word production tasks, was compared to that of neurologically intact controls, and patient controls with lesions that spared the cerebellar speech production regions. Our analyses revealed that, during a range of speech production tasks, patients with damage to cerebellar speech production regions had greater activation in the right dorsal premotor cortex (r-PMd) and right supplementary motor area (r-SMA) compared to neurologically intact controls. The loci of increased activation in cerebral motor speech areas motivate future studies to delineate the functional contributions of different parts of the speech production network, and test whether non-invasive stimulation to r-PMd and r-SMA facilitates speech recovery after cerebellar stroke.