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Details

Autor(en) / Beteiligte
Titel
Conventional Frequency Ultrasonic Biomarkers of Cancer Treatment Response In Vivo
Ist Teil von
  • Translational oncology, 2013-06, Vol.6 (3), p.234-IN2
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2013
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
  • Abstract BACKGROUND: Conventional frequency quantitative ultrasound in conjunction with textural analysis techniques was investigated to monitor noninvasively the effects of cancer therapies in an in vivo preclinical model. METHODS: Conventional low-frequency (∼7 MHz) and high-frequency (∼20 MHz) ultrasound was used with spectral analysis, coupled with textural analysis on spectral parametric maps, obtained from xenograft tumor-bearing animals ( n = 20) treated with chemotherapy to extract noninvasive biomarkers of treatment response. RESULTS: Results indicated statistically significant differences in quantitative ultrasound-based biomarkers in both low- and high-frequency ranges between untreated and treated tumors 12 to 24 hours after treatment. Results of regression analysis indicated a high level of correlation between quantitative ultrasound-based biomarkers and tumor cell death estimates from histologic analysis. Applying textural characterization to the spectral parametric maps resulted in an even stronger correlation ( r2 = 0.97). CONCLUSION: The results obtained in this research demonstrate that quantitative ultrasound at a clinically relevant frequency can monitor tissue changes in vivo in response to cancer treatment administration. Using higher order textural information extracted from quantitative ultrasound spectral parametric maps provides more information at a high sensitivity related to tumor cell death.
Sprache
Englisch
Identifikatoren
ISSN: 1936-5233
eISSN: 1936-5233
DOI: 10.1593/tlo.12385
Titel-ID: cdi_crossref_primary_10_1593_tlo_12385
Format
Schlagworte
Oncology

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