Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Annual review of cell and developmental biology, 2001-01, Vol.17 (1), p.569-614
2001

Details

Autor(en) / Beteiligte
Titel
GETTING THE MESSAGE ACROSS: The Intracellular Localization of mRNAs in Higher Eukaryotes
Ist Teil von
  • Annual review of cell and developmental biology, 2001-01, Vol.17 (1), p.569-614
Ort / Verlag
Palo Alto, CA 94303-0139: Annual Reviews
Erscheinungsjahr
2001
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
  • The intracellular localization of mRNA, a common mechanism for targeting proteins to specific regions of the cell, probably occurs in most if not all polarized cell types. Many of the best characterized localized mRNAs are found in oocytes and early embryos, where they function as localized determinants that control axis formation and the development of the germline. However, mRNA localization has also been shown to play an important role in somatic cells, such as neurons, where it may be involved in learning and memory. mRNAs can be localized by a variety of mechanisms including local protection from degradation, diffusion to a localized anchor, and active transport, and we consider the evidence for each of these processes, before discussing the cis -acting elements that direct the localization of specific mRNAs and the trans -acting factors that bind them.

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX