Canadian journal of physiology and pharmacology, 2012-05, Vol.90 (5), p.663-668
2012
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Details
- Autor(en) / Beteiligte
- Titel
- MK-626, a dipeptidyl peptidase-4 inhibitor, does not improve the hyperglycemia or hyperinsulinemia of nonobese diabetic MKR mice
- Ist Teil von
- Canadian journal of physiology and pharmacology, 2012-05, Vol.90 (5), p.663-668
- Ort / Verlag
- Canada
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Dipeptidyl peptidase-4 (DPP-4) inhibitors increase circulating levels of incretin hormones, which can enhance insulin secretion and β cell function. The aim of this study was to evaluate the effectiveness of MK-626 (a novel DPP-4 inhibitor) to reduce the hyperglycemia and hyperinsulinemia of nonobese type 2 diabetic MKR mice. Twelve to 14-week-old hyperglycemic MKR mice were gavaged daily with MK-626 (3 mg/kg body weight) or vehicle (0.5% methyl cellulose (MC)) for 2 weeks. MK-626-treated mice displayed no change in body weight or adverse reactions, suggesting good tolerance of the drug. Fed blood glucose was significantly reduced over the 2-week experiment; however, it was also reduced in the MC group, suggesting an effect of gavage alone. Fed plasma insulin and glucagon levels and glucose tolerance of MK-626-treated mice were similar to those of MC mice. Therefore, treatment with MK-626 did not correct the prolonged hyperglycemia and impaired glucose tolerance of MKR mice.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0008-4212eISSN: 1205-7541DOI: 10.1139/y2012-039Titel-ID: cdi_crossref_primary_10_1139_y2012_039
- Format
- –
- Schlagworte
- Animals, Blood Glucose - drug effects, Blood Glucose - metabolism, Body Weight - drug effects, Diabetes Mellitus, Experimental - blood, Diabetes Mellitus, Experimental - drug therapy, Diabetes Mellitus, Experimental - metabolism, Dipeptidyl-Peptidase IV Inhibitors - pharmacology, Glucagon - blood, Glucagon - metabolism, Glucose - metabolism, Glucose Intolerance - drug therapy, Glucose Intolerance - metabolism, Homeostasis - drug effects, Hyperglycemia - blood, Hyperglycemia - drug therapy, Hyperglycemia - metabolism, Hyperinsulinism - blood, Hyperinsulinism - drug therapy, Hyperinsulinism - metabolism, Incretins - blood, Incretins - metabolism, Insulin - blood, Insulin - metabolism, Insulin Secretion, Islets of Langerhans - drug effects, Islets of Langerhans - metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, Obese - blood, Mice, Obese - metabolism, Phenylalanine - analogs & derivatives, Phenylalanine - pharmacology, Triazoles - pharmacology