Antimicrobial agents and chemotherapy, 2020-02, Vol.64 (3)
2020
Details
- Autor(en) / Beteiligte
- Titel
- In Vivo Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the Aotus Monkey-Human Malaria Model
- Ist Teil von
- Antimicrobial agents and chemotherapy, 2020-02, Vol.64 (3)
- Ort / Verlag
- United States: American Society for Microbiology
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- Nonimmune monkeys infected with and were cured of their infections when treated with a single oral dose of 5 mg/kg and 10 mg/kg of the 2-aminomethylphenol, JPC-3210, respectively. Corresponding mean blood elimination half-lives of JPC-3210 were lengthy at 19.1 days and 20.5 days, respectively. This potency and lengthy half-life supports the further development of JPC-3210 as a promising, long-acting blood schizontocidal antimalarial for malaria treatment and prevention.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0066-4804eISSN: 1098-6596DOI: 10.1128/AAC.01538-19Titel-ID: cdi_crossref_primary_10_1128_AAC_01538_19
- Format
- –
- Schlagworte
- Animals, Antimalarials, Aotidae, Female, Humans, Malaria - drug therapy, Malaria, Falciparum - drug therapy, Malaria, Falciparum - prevention & control, Malaria, Vivax - drug therapy, Malaria, Vivax - prevention & control, Male, Plasmodium falciparum - drug effects, Plasmodium falciparum - pathogenicity, Plasmodium vivax - drug effects, Plasmodium vivax - pathogenicity, Susceptibility