Autor(en)
McCallum, Fiona J; Birrell, Geoffrey W; Chavchich, Marina; Harris, Ivor; Obaldia, Nicanor; Van Breda, Karin; Heffernan, Gavin D; Jacobus, David P; Shanks, Dennis; Edstein, Michael D
Titel
In Vivo Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the Aotus Monkey-Human Malaria Model
Teil von
  • Antimicrobial agents and chemotherapy, 2020-03-01, Vol.64 (3)
Ort / Verlag
WASHINGTON: AMER SOC MICROBIOLOGY
Links zum Volltext
Quelle
HighWire Press (Free Journals)
Beschreibungen
Nonimmune Aotus monkeys infected with Plasmodium falciparum and Plasmodium vivax were cured of their infections when treated with a single oral dose of 5 mg/kg and 10 mg/kg of the 2-aminomethylphenol, JPC-3210, respectively. Corresponding mean blood elimination half-lives of JPC-3210 were lengthy at 19.1 days and 20.5 days, respectively. This in vivo potency and lengthy half-life supports the further development of JPC-3210 as a promising, long-acting blood schizontocidal antimalarial for malaria treatment and prevention.

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