Details

Autor(en) / Beteiligte

• Ruedas-Torres, I.
• Rodríguez-Gómez, I.M.
• Sánchez-Carvajal, J.M.
• Larenas-Muñoz, F.
• Pallarés, F.J.
• Carrasco, L.
• Gómez-Laguna, J.

Titel

The jigsaw of PRRSV virulence

Ist Teil von

• Veterinary microbiology, 2021-09, Vol.260, p.109168, Article 109168

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• •High mortality, severe clinical signs and lesions are associated with selected PRRSV strains.•Terminology used during the description of “virulent” PRRSV outbreaks is revised.•Immunopathological characteristics of “virulent” and classical PRRSV strains are reviewed.•An approximation to the criteria to define a “virulent” PRRSV strain is proposed. Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of the, probably, most economically important disease for the pig industry worldwide. This disease, characterised by producing reproductive failure in sows and respiratory problems in growing pigs, appeared in the late 1980s in the United States and Canada. Since its appearance, strains capable of producing higher mortality rates as well as greater severity in clinical signs and lesions than classical strains have been identified. However, since the first reports of these “virulent” PRRSV outbreaks, no homogeneity and consensus in their description have been established. Moreover, to the authors’ knowledge, there is no published information related to the criteria that a PRRSV strain should fulfil to be considered as a “virulent” strain. In this review, we revise the terminology used and gather the information related to the main characteristics and differences in clinical signs, lesions, viral replication and tropism as well as immunological parameters between virulent and classical PRRSV strains and propose a first approximation to the criteria to define a virulent PRRSV strain.