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Details

Autor(en) / Beteiligte
Titel
High serum levels of p,p’-DDE are associated with an accelerated decline in GFR during 10 years follow-up
Ist Teil von
  • The Science of the total environment, 2018-12, Vol.644, p.371-374
Ort / Verlag
Elsevier B.V
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
  • Over the past 20 years, the global incidence of chronic kidney disease (CKD) has been increasing and organochlorine pesticides (such as DDT) is a suspected etiological factor. The present study examines the associations between low level background exposure to p,p’-DDE (1-dichloro-2,2-bis (p-chlorophenyl) ethylene), the main DDT metabolite, and kidney function during a 10-year follow-up. Data was analysed from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (n = 1016, 50% women, all aged 70 years). Serum levels of p,p’-DDE was measured by gas chromatography coupled to high-resolution mass spectrometry (GC/HRMS) at baseline (i.e. age of 70 years). Glomerular filtration rate (GFR) was estimated using serum creatinine and cystatin C at 70, 75 and 80 years of age. A significant decline in GFR was seen during the 10-year follow-up (−24 ml/min/1.73 m2, p < 0.0001). A significant negative interaction was seen between baseline p,p’-DDE levels and change in GFR over time (p < 0.0001) following adjustment for sex, systolic blood pressure, diabetes, BMI, smoking and education level at age 70. Subjects with the lowest levels of p,p’-DDE levels at age 70 showed the lowest decline in GFR over 10 years, while subjects with the highest p,p’-DDE levels showed the greatest decline. Baseline levels of p,p’-DDE were related to an accelerated reduction in GFR over 10 years suggesting a nephrotoxic effect of DDT/p,p’-DDE. These findings support a potential role for DDT in the epidemic of CKD of unknown etiology (CKDu) in agricultural communities of Sri Lanka and Central America where DDT was previously used. Q1, Q2, Q3 = tertiles of p,p’-DDE levels at baseline at 70 years. [Display omitted] •Organochlorine pesticides are suspected etiological factors of chronic kidney disease.•p,p’-DDE levels were associated with an accelerated reduction in renal function over 10 years.•The results support nephrotoxicity from DDT/p,p’-DDE.

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