Journal of neuroscience methods, 2011-03, Vol.196 (1), p.118-123
2011
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Details
- Autor(en) / Beteiligte
- Titel
- Design of an in-dwelling cannula for convection-enhanced delivery
- Ist Teil von
- Journal of neuroscience methods, 2011-03, Vol.196 (1), p.118-123
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- ▶ A novel cannula for convection-enhanced delivery (CED) trials is presented. ▶ The cannula is in-dwelling, MRI-compatible and reflux-resistant. ▶ The cannula is designed for use in upcoming trials in neuro-oncology and neurodegeneration. ▶ The cannula performance is validated in non-human primate infusions. Failures of recent convection-enhanced delivery (CED) trials have underscored the need for improved CED cannulae. This study presents a novel in-dwelling cannula targeted for use in upcoming neuro-oncological or neurodegeneration trials. The cannula is reflux-resistant and easily integrated into clinical workflows. The cannula was evaluated in non-human primate CED studies performed with magnetic resonance imaging (MRI) to validate the effectiveness and safety of the infusion.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0165-0270eISSN: 1872-678XDOI: 10.1016/j.jneumeth.2010.12.022Titel-ID: cdi_crossref_primary_10_1016_j_jneumeth_2010_12_022
- Format
- –
- Schlagworte
- Animals, Brain - anatomy & histology, Cannula, Catheterization - instrumentation, Contrast Media - administration & dosage, Convection, Convection-enhanced delivery, Drug Delivery Systems - instrumentation, Equipment Design, Follow-Up Studies, Gadolinium, Heterocyclic Compounds - administration & dosage, Infusion, Macaca mulatta, Magnetic Resonance Imaging, MRI, Neuro-oncology, Neurodegeneration, Non-human primate, Organometallic Compounds - administration & dosage, Primates, Reproducibility of Results