Details

Autor(en) / Beteiligte

• La Merrill, M.A.
• Lind, P.M.
• Salihovic, S.
• van Bavel, B.
• Lind, L.

Titel

The association between p,p′-DDE levels and left ventricular mass is mainly mediated by obesity

Ist Teil von

• Environmental research, 2018-01, Vol.160, p.541-546

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• The pesticide metabolite p,p′-DDE has been associated with left ventricular (LV) mass and known risk factors for LV hypertrophy in humans and in experimental models. We hypothesized that the associations of p,p′-DDE with LV hypertrophy risk factors, namely elevated glucose, adiposity and hypertension, mediate the association of p,p′-DDE with LV mass. p,p′-DDE was measured in plasma from 70-year-old subjects (n = 988) of the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). When these subjects were 70-, 75- and 80- years old, LV characteristics were measured by echocardiography, while fasting glucose, body mass index (BMI) and blood pressure were assessed with standard clinical techniques. We found that p,p′-DDE levels were associated with increased fasting glucose, BMI, hypertension and LV mass in separate models adjusted for sex. Structural equation modeling revealed that the association between p,p′-DDE and LV mass was almost entirely mediated by BMI (70%), and also by hypertension (19%). The obesogenic effect of p,p′-DDE is a major determinant responsible for the association of p,p′-DDE with LV mass. [Display omitted] •p,p′-DDE is associated with increased adiposity, glucose, hypertension, and LV mass.•The association of p,p′-DDE with LV mass is primarily mediated by adiposity.•The association of p,p′-DDE with LV mass is also mediated by hypertension.