Journal of materials science. Materials in medicine, 2013-12, Vol.24 (12), p.2749-2760
2013
Details
- Autor(en) / Beteiligte
- Titel
- The association of hydrogel and biphasic calcium phosphate in the treatment of dehiscence-type peri-implant defects: an experimental study in dogs
- Ist Teil von
- Journal of materials science. Materials in medicine, 2013-12, Vol.24 (12), p.2749-2760
- Ort / Verlag
- Boston: Springer US
- Erscheinungsjahr
- 2013
- Link zum Volltext
- Quelle
- SpringerNature Journals
- Beschreibungen/Notizen
- Hydrogel polymers have many applications in regenerative medicine. The aim of this study in dogs was to investigate bone regeneration in dehiscence-type peri-implant defects created surgically and treated with (i) biphasic calcium phosphate (BCP) granules alone; (ii) a composite putty hydroxypropyl methylcellulose (HPMC)/BCP (MBCP/putty); and (iii) a polymer crosslinked membrane of silanized-HPMC (Si-HPMC/BCP) compared with empty controls. At 3 months, new bone formation was significantly more important in defects filled with HPMC/BCP or Si-HPMC/BCP compared with spontaneous healing in control ( P = 0.032 and P = 0.046 respectively) and more substantial compared with BCP alone. Furthermore, new bone formation in direct contact with the implant surface was observed in all three groups treated with BCP. The addition of HPMC to the BCP granules may have enhanced the initial stability of the material within the blood clot in these large and complex osseous defects. The Si-HPMC hydrogel may also act as an occlusive membrane covering the BCP, which could improve the stability of the granules in the defect area. However, the crosslinking time of the Si-HPMC is too long for easy handling and the mechanical properties remain to be improved. The composite MBCP/putty appears to be a valuable bone-graft material in complex defects in periodontology and implantology. These encouraging results should now be confirmed in clinical studies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0957-4530eISSN: 1573-4838DOI: 10.1007/s10856-013-5019-xTitel-ID: cdi_crossref_primary_10_1007_s10856_013_5019_x
- Format
- –
- Schlagworte
- Animals, Biocompatible Materials - chemistry, Biological and medical sciences, Biomaterials, Biomedical Engineering and Bioengineering, Biomedical materials, Bone Regeneration, Bone Substitutes - chemistry, Bones, Calcium phosphate, Calcium phosphates, Calcium Phosphates - chemistry, Ceramics, Chemistry and Materials Science, Composites, Cross-Linking Reagents - chemistry, Crosslinking, Defects, Dogs, Geriatry and gerontology, Glass, Granular materials, Granules, Human health and pathology, Hydrogels, Hydrogels - chemistry, Hydroxyapatites - chemistry, Hypromellose Derivatives, Life Sciences, Materials Science, Medical sciences, Membranes, Artificial, Methylcellulose - analogs & derivatives, Methylcellulose - chemistry, Natural Materials, Osseointegration, Polymer Sciences, Polymers - chemistry, Prostheses and Implants, Regenerative Medicine/Tissue Engineering, Rhumatology and musculoskeletal system, Stress, Mechanical, Surfaces and Interfaces, Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases, Technology. Biomaterials. Equipments, Thin Films, Transplants & implants, Wound Healing