Details

Autor(en) / Beteiligte

• Kaihan, Ahmad Baseer
• Yasuda, Yoshinari
• Katsuno, Takayuki
• Kato, Sawako
• Imaizumi, Takahiro
• Ozeki, Takaya
• Hishida, Manabu
• Nagata, Takanobu
• Ando, Masahiko
• Tsuboi, Naotake
• Maruyama, Shoichi

Titel

The Japanese Histologic Classification and T-score in the Oxford Classification system could predict renal outcome in Japanese IgA nephropathy patients

Ist Teil von

• Clinical and experimental nephrology, 2017-12, Vol.21 (6), p.986-994

Ort / Verlag

Tokyo: Springer Japan

Erscheinungsjahr

2017

Link zum Volltext

Quelle

SpringerNature Journals

Beschreibungen/Notizen

• Background The Oxford Classification is utilized globally, but has not been fully validated. In this study, we conducted a comparative analysis between the Oxford Classification and Japanese Histologic Classification (JHC) to predict renal outcome in Japanese patients with IgA nephropathy (IgAN). Methods A retrospective cohort study including 86 adult IgAN patients was conducted. The Oxford Classification and the JHC were evaluated by 7 independent specialists. The JHC, MEST score in the Oxford Classification, and crescents were analyzed in association with renal outcome, defined as a 50% increase in serum creatinine. Results In multivariate analysis without the JHC, only the T score was significantly associated with renal outcome. While, a significant association was revealed only in the JHC on multivariate analysis with JHC. Conclusions The JHC and T score in the Oxford Classification were associated with renal outcome among Japanese patients with IgAN. Superiority of the JHC as a predictive index should be validated with larger study population and cohort studies in different ethnicities.