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Growth deceleration of children on inhaled corticosteroids is compensated for after the first 12 months of treatment
Pediatric pulmonology, 2007-05, Vol.42 (5), p.465-470
Anthracopoulos, Michael B.
Papadimitriou, Anastasios
Panagiotakos, Demosthenes B.
Syridou, Garyfalia
Giannakopoulou, Eleni
Fretzayas, Andrew
Nicolaidou, Polyxeni
Priftis, Kostas N.
2007
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Anthracopoulos, Michael B.
Papadimitriou, Anastasios
Panagiotakos, Demosthenes B.
Syridou, Garyfalia
Giannakopoulou, Eleni
Fretzayas, Andrew
Nicolaidou, Polyxeni
Priftis, Kostas N.
Titel
Growth deceleration of children on inhaled corticosteroids is compensated for after the first 12 months of treatment
Ist Teil von
Pediatric pulmonology, 2007-05, Vol.42 (5), p.465-470
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2007
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Timing and duration of linear growth suppression in children on long‐term inhaled corticosteroids (ICS) are not entirely clear; we undertook a “pragmatic” study to determine growth of asthmatic children on long‐term ICS managed by a flexible dosing step‐down approach. Standard deviation scores of height (HSDS), height velocity (HVSDS), and body mass index (BMISDS) of pre‐pubertal asthmatic children on maintenance therapy with either budesonide (BUD) or fluticasone propionate (FP) were calculated in a prospective open‐label non‐randomized study. Outcomes were recorded at initiation of ICS, 6, 12, 24, and 36 months, as applicable, and 6 months after ICS treatment discontinuation. Three hundred twenty‐two children on BUD and 319 on FP were enrolled after the completion of 6‐month treatment. The median (range) daily dose at initiation was 400 mcg (400–1,200) and 200 mcg (200–500), the final maintenance 200 mcg (200–400) and 100 mcg (100–200), respectively. In the first 6–12 months, a decrease in HSDS of approximately 18% below baseline values was noted (P < 0.01) that was restored to almost baseline average levels by 24 months, and slightly increased to above baseline during the third year. HVSDS showed a linear increase in both treatment arms (P < 0.01). No differences were found between the two treatment arms regarding HSDS, HVSDS, and BMISDS at any time point over the course of the study. In conclusion, growth deceleration of asthmatic children on maintenance ICS is compensated for after the first 12 months of treatment. This effect does not differ between BUD and FP treatment, despite some variation in the pattern of linear growth. Pediatr Pulmonol. 2007; 42:465–470. © 2007 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 8755-6863
eISSN: 1099-0496
DOI: 10.1002/ppul.20598
Titel-ID: cdi_crossref_primary_10_1002_ppul_20598
Format
–
Schlagworte
Administration, Inhalation
,
Age Factors
,
Androstadienes - administration & dosage
,
Androstadienes - adverse effects
,
asthma
,
Asthma - drug therapy
,
Asthma - physiopathology
,
Biological and medical sciences
,
Body Size - drug effects
,
Bones, joints and connective tissue. Antiinflammatory agents
,
budesonide
,
Budesonide - administration & dosage
,
Budesonide - adverse effects
,
Chronic obstructive pulmonary disease, asthma
,
Female
,
Fluticasone
,
fluticasone propionate
,
General aspects
,
Glucocorticoids - administration & dosage
,
Glucocorticoids - adverse effects
,
Humans
,
linear growth
,
Male
,
Medical sciences
,
Pharmacology. Drug treatments
,
Pneumology
,
Prospective Studies
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