Details

Autor(en) / Beteiligte

• Malacinski, George M[Herausgeber]
• Klein, William H[Herausgeber]

Titel

Molecular Aspects of Early Development

Ort / Verlag

Boston, MA : Springer US

Erscheinungsjahr

1984

Link zum Volltext

• Volltext

Beschreibungen/Notizen

• The Yellow Crescent of Ascidian Eggs: Molecular Organization, Localization and Role in Early Development -- Expression of Maternal and Embroyonic Genes During Sea Urchin Development -- Translational Regulation of Gene Expression in Early Development -- mRNA Distributions in Sea Urchin Embryos -- Subcellular Localization of Maternal Histone mRNAs and The Control of Histone Synthesis in The Sea Urchin Embryo -- A Family of mRNAs Expressed in The Dorsal Ectoderm of Sea Urchin Embryos -- Segregation of Germ-Line-Specific Antigens During Embryogenesis in Caenorhabditis Elegans -- Genetic and Developmental Approaches to Understanding Determination in Early Development -- Homoeotic Genes and The Specification of Segmental Identity in The Embryo and Adult Thorax of Drosophila Melanogaster -- Isolation and Characterization of Genes Differentially Expressed in Early Drosophila Embryogenesis -- Accumulation and Behavior of mRNA During Oogenesis and Early Embryogenesis of Xenopus Laevis -- Prot
• The early embryo has emerged as the focal point for analysis of the regulation of gene expression for several reasons. First, the fact that embryogenesis is under genetic control has been appreciated from the earliest days of classical embryology. When experimental techniques became available it was therefore logical that they should be applied to the embryo. With each new advance in methodology, interest in embryonic gene expression studies has increased. Second, many embryos offer unique opportunities for the investigation of specific aspects of the regulation of gene expression. Several phenomena--eg. , control of translation--can be very conveniently studied in a variety of marine invertebrate embryos. Those embryos contain large stores of maternally inherited mRNA which are translated in a highly ordered fashion during specific stages of post fertilization development. Marine invertebrate eggs can be conveniently artifically inseminated and labeled with radioactive precursors. Their analysis is leading to important insights into the mechanisms which regulate gene expression at post-transcriptional levels. Third, recent advances in both transmission and recombinant DNA genetics, especially in organisms such as Drosophila, are providing special opportunities for the analysis of regulatory mechanisms which operate at the level of the genome. Specific genes have been identified, isolated, and--in some instances--sequenced. The opportunity is now available to study the regulation of the expression of single genes in a vertical fashion--from the primary sequence of the gene to the tissues and organs which are the products of morphogenesis