Details

Autor(en) / Beteiligte

• Libuda, Lars
• Filipiak-Pittroff, Birgit
• Standl, Marie
• Schikowski, Tamara
• Berg, Andrea <<von>>
• Heinrich, Joachim
• Berdel, Dietrich
• Gappa, Monika
• Koletzko, Sibylle
• Bauer, Carl-Peter

Titel

Full breastfeeding and allergic diseases—long-term protection or rebound effects?

Ist Teil von

• nutrients. Special issue, Band 15 (2023), 2780, Seite 1-15 (Alle Bände)

Ort / Verlag

Paderborn : Universitätsbibliothek

Erscheinungsjahr

2023

Link zu anderen Inhalten

• Volltext
• Volltext

Beschreibungen/Notizen

• Open Access
• eng: A previous follow-up of the GINIplus study showed that breastfeeding could protectagainst early eczema. However, effects diminished in adolescence, possibly indicating a “reboundeffect” in breastfed children after initial protection. We evaluated the role of early eczema until threeyears of age on allergies until young adulthood and assessed whether early eczema modifies the associationbetween breastfeeding and allergies. Data from GINIplus until 20-years of age (N = 4058) wereconsidered. Information on atopic eczema, asthma, and rhinitis was based on reported physiciansdiagnoses. Adjusted Odds Ratios (aOR) were modelled by using generalized estimating equations.Early eczema was associated with eczema (aORs = 3.2-14.4), asthma (aORs = 2.2-2.7), and rhinitis(aORs = 1.2-2.7) until young adulthood. For eczema, this association decreased with age (p-forinteraction= 0.002-0.006). Longitudinal models did not show associations between breastfeeding andthe respective allergies from 5 to 20 years of age. Moreover, early eczema generally did not modifythe association between milk feeding and allergies except for rhinitis in participants without familyhistory of atopy. Early eczema strongly predicts allergies until young adulthood. While preventiveeffects of full breastfeeding on eczema in infants with family history of atopy does not persist untilyoung adulthood, the hypothesis of a rebound effect after initial protection cannot be confirmed.