Details

Autor(en) / Beteiligte

• Schlaepfer, Thomas E
• Nemeroff, Charles B

Titel

Neurobiology of psychiatric disorders [electronic resource]

Beschreibungen/Notizen

• Description based upon print version of record.
• Includes bibliographical references and index.
• Front Cover; Neurobiology of Psychiatric Disorders; Copyright; Available titles; Foreword; Preface; Contributors; Contents; Chapter 1: Psychiatry and neuroscience - history; Neuroscience and the History And theory of Science; Theories and Concepts of Localization and Genetics; Historical Epistemologies of Neuroscience - Picturing The brain; Neuroscience and Psychiatric Disorders - Dementia as a Model for the Interdependence of Basic and Clinical Science...; References; Chapter 2: Receptor signaling and the cell biology of synaptictransmission; Introduction; Methods for Receptor Analysis
• Radioligand BindingReceptor Quantitation; Kinetics of Receptor Binding; Modulation of Receptor affinity By G Protein; G Protein-coupled Receptor Signaling; Changes in Receptor Confirmation Upon Agonist Activation; Inverse Agonism; Regulation of Receptor Sensitivity; Receptor Desensitization; Heterologous Desensitization; Homologous Desensitization; Heterotrimeric G Proteins: the Next step in the Signaling Cascade; RGS Proteins; Microdomains in the Plasma Membrane And Gpcrs Signaling; G Protein Effectors; Adenylyl Cyclase; Insight to Adenylyl Cyclase From Its crystal structure
• Phospholipid Metabolism Mediated By G Protein-dependent Hormone SignalsPhospholipase A2; Phospholipase C; Phospholipase D; G Protein-activated Ion Channels; G Proteins and Changes in Cell Structure; Cellular Integration of Second-messenger signals; Cyclic Nucleotide Phosphodiesterase; The Intracellular Amplification Of extracellular Signals; Second Messenger-activated protein Kinases; cAmp-dependent Protein Kinases; Exchange Proteins Activated By CAmp; cGmp-dependent Protein Kinases; Nitric Oxide and CGmp Signaling; Changes in Intracellular Calcium; Intracellular Calcium Channels
• Calcium-binding ProteinsCalmodulin; Calcium/calmodulin-dependent Protein Kinases (CaM Kinases); Protein Kinase C; Phosphoprotein Phosphatases; Serine/threonine Phosphatases; Localization of Phosphatase Signaling; Interplay Between Calcium/calmodulin And cAmp Signaling; Ionotropic Receptors; The Nicotinic Acetylcholine Receptor; Glutamate Receptors; Gaba Receptors; Glycine Receptors; 5Ht3 Serotonin Receptor; Receptors With Tyrosine Kinase Activity; Kinase Cascades Promoting Cell Growth Or neuronal Differentiation; Protein Tyrosine Phosphatase; Effects of CAmp on Gene Transcription
• Neurobiology of Creb Family ProteinsNuclear Receptor Signaling; Cross-talk Among Receptor Signaling Systems: Contribution to Synaptic Plasticity; References; Chapter 3: Human genetics of schizophrenia; The Genetic Background Of schizophrenia; Linkage Studies; 6p24-p22; 13q14-q32; 1q21-q22; 8p22-p11; 22q11-q13.1; Meta-analyses; Candidate Genes for Schizophrenia Supported By linkage Findings; G72/G30; Rgs4; Nos1Ap; Nrg1; Dntbp1; Cytogenetic Evidence Supporting Specific Genes in Risk for Schizophrenia; Disc1; 22q11 Deletion Syndrome; Prodh2; Genomewide Association Studies of Schizophrenia
• Copy Number Variation: a Newly Appreciated Genetic Contribution to Schizophrenia
• This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder, and similar results hold for Europe. Now that neurology and psychiatry agree t
• English