Details

Autor(en) / Beteiligte

• Zhang, Li-He,
• Tang, Xinjing,
• Xi, Zhen,

Titel

Nucleic acids in medicinal chemistry and chemical biology : drug development and clinical applications

Ort / Verlag

Hoboken, NJ : John Wiley & Sons, Incorporated,

Erscheinungsjahr

2023

Beschreibungen/Notizen

• Includes bibliographical references and index.
• Chapter 1. Phosph(on)ate Prodrugs-prof.Junbiao Chang.docx chapter 2-Cyclic Dinucleotides A New Generation Drug for Immune Therapy-prof Xi.docx Chapter 3-Enzymatic and Endogenous Synthesis of NAD(P)-derived Calcium-mobilizing Messengers-Prof Lee.docx Chapter 4-Selenium Atom-modified Nucleic Acids for Structural, Functional and Diagnostic Studies-prof huang.docx chapter 5-Sequence-specific chromosomal DNA binders an unfulfilled promise-Prof Sugiyama.docx chapter 6- DNA synthesis and synthetic genome-prof Yuan.docx Chapter 7-Methods for mapping of nucleic acids epigenetic modifications and its clinic applications-prof zhou.docx Chapter 8-main text.docx Chapter 9-nucleic acid-based nanocarriers as drug delivry system-Prof. Jongbum Lee-no figure.docx Chapter 10.docx Chapter 11-Oligonucleotide therapeutics-Prof. Yang.docx Chapter 12-CRISPRCas9 a therapeutic solution by manipulating nucleic acids-prof.Deng.docx chapter 13-Aptamer properties, functions and applications-prof Tan.docx chapter 14-G-quadruplex as a platform for new perspectives in nucleic acid targeting for therapeutic applications-Prof.Sissi.doc.
• "This book delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field"--
• Description based on publisher supplied metadata and other sources.