Details

Autor(en) / Beteiligte

• Payne, Susan,

Titel

Viruses : from understanding to investigation

Auflage

2nd ed

Ort / Verlag

Amsterdam, Netherlands : Elsevier,

Erscheinungsjahr

[2022]

Link zum Volltext

• Elsevier Books AutoHoldings

Beschreibungen/Notizen

• Front Cover -- Viruses -- Copyright Page -- Contents -- About the author -- Preface -- Acknowledgments -- 1 Introduction to animal viruses -- What is a virus? -- Diversity in the world of viruses -- Are viruses alive? -- Basic steps in the virus replication-cycle -- Propagating viruses -- Categorizing viruses (taxonomy) -- Outcomes of viral infection -- Introduction to viral pathogenesis -- Introduction to viral transmission -- References -- 2 Virus structure -- Anatomy of a virus -- Capsid structure and function -- Capsids are built using many copies of one or a few types of protein -- Simple icosahedral capsids -- Larger icosahedral capsids -- Polyomavirus and papillomavirus capsids -- Adenovirus capsids -- Reoviruses -- Herpesvirus capsids -- Surface structures of capsids -- Viral envelopes -- Glycosylation -- Other membrane proteins -- Matrix proteins -- Nucleocapsid structure -- References -- 3 Virus interactions with the cell -- Virion attachment -- The extracellular space -- The plasma membrane -- Attachment -- Virus penetration and uncoating -- Virus penetration and uncoating of unenveloped viruses -- Virus penetration and uncoating of enveloped viruses -- Movement through the cell, interactions with the cytoskeleton -- Amplification of viral proteins and nucleic acids in the context of the infected cell -- A short review of transcription in the eukaryotic cell -- Transcription of viral mRNAs -- A short review of translation in the eukaryotic host cell -- Translation of viral proteins -- Synthesis of viral genomes -- The endgame: virus assembly, release, and maturation -- Assembly -- Virion release -- Virion maturation -- 4 Methods to study viruses -- Growing viruses -- Generating cell cultures -- Purifying viruses -- Visualizing viruses -- Optical microscopy -- Electron microscopy -- Counting viruses -- Infectivity assays.
• Chemical/physical methods of virus quantitation -- Direct visualization by electron microscopy -- Hemagglutination assay -- Serological assays -- Enzyme-linked immunosorbent assays -- Western blots -- Genome detection and quantitation by PCR -- Basic principles of diagnostic virology -- Deep sequencing for virus discovery and characterization -- References -- 5 Virus transmission and epidemiology -- Modes of transmission -- Respiratory routes -- Food and water -- Exchange of body fluids -- Insect vectors -- Role of the host specificity in virus transmission -- Transmissibility -- Describing viral infection and disease -- Infection versus disease -- Pathogenicity and virulence -- Acute versus persistent infection -- Incubation, latent, and infectious periods -- Incidence versus prevalence -- 6 Immunity and resistance to viruses -- What is immunity? -- Innate immunity -- Pattern recognition receptors -- Toll-like receptors -- Retinoic acid-inducible gene-like receptors -- Nucleotide-binding oligomerization domain (NOD)-like receptors -- Pyrin and HIN200 domain-containing proteins -- Cyclic GMP-AMP synthase -- Adapter proteins: next level players in innate immunity -- Inflammasomes -- Other proinflammatory molecules -- Interferons -- Type-I interferons -- Type-II interferon -- Type-III interferons -- JAK-STAT signaling -- Interferon-stimulated genes and the antiviral state -- Protein kinase RNA-activated pathway -- 2′-5′ Oligo A synthase pathway -- Other interferon-stimulated genes -- Intrinsic immunity -- Restriction factors -- Autophagy -- Natural killer cell responses to viral infection -- Specific immunity -- Antibody responses -- Cell-mediated responses -- Antigen presentation -- Viruses fight back -- Antigenic variation -- Suppression of antigen presentation -- Suppression of interferon responses -- Immunosuppression.
• Poxviruses encode molecules that mimic cytokines, interferons, and their receptors -- Hiding from the immune system -- Micro-RNAs -- 7 Viral vaccines -- Vaccines provide a source of antigen -- Antigen recognition -- Classical versus engineered vaccines -- Replicating versus inactivated vaccines -- Viral vaccines that contain infectious agents -- Killed, inactivated, and subunit vaccines -- Correlates of protection -- Vaccine development and assessment of efficacy -- COVID-19 vaccines -- A final word about safety -- References -- 8 Antiviral agents -- Inhibitors of attachment, entry, or uncoating -- Inhibitors of viral nucleic acid synthesis -- Protease inhibitors -- Neuraminidase inhibitors -- Interferons -- The future of antivirals -- 9 Virus evolution and genetics -- Virus evolution -- Measuring virus evolution -- Point mutation -- Recombination -- Reassortment -- Genotypes and phenotypes -- Essential and nonessential genes -- Coevolution of virus and host -- Genetic manipulation of viruses -- Reverse genetics of positive-strand RNA viruses -- Reverse genetics of negative-strand RNA viruses -- Reverse genetics of retroviruses -- Reverse genetics of small DNA viruses -- Reverse genetics of large DNA viruses -- 10 Viral pathogenesis -- Natural barriers to infection -- Primary replication -- Movement to secondary replication sites -- Genesis of disease -- Immunopathogenesis -- Virulence -- Approaches to study viral pathogenesis -- Virally induced cancers -- 11 Introduction to RNA viruses -- Definition and basic properties of RNA viruses -- Positive-strand RNA viruses -- Negative-sense RNA, ambisense, and double-stranded RNA viruses -- Negative-sense RNA viruses -- Ambisense RNA viruses -- dsRNA viruses -- Hepatitis delta virus uses host DNA-dependent RNA polymerase for replication -- Structural features of RNA virus genomes.
• Priming viral RNA synthesis -- Mechanisms to generate capped mRNAs -- Mechanisms to generate polyadenylated mRNAs -- Mechanisms to regulate synthesis of genomes and transcripts -- RNA viruses and quasispecies -- References -- 12 Family Picornaviridae -- Genome organization -- Virion structure -- Picornavirus replication (poliovirus model) -- Binding and penetration -- Translation -- Genome replication -- Assembly and maturation -- Diseases caused by picornaviruses -- Genus enterovirus -- Genus hepatovirus -- Genus kobuvirus -- Genus parechovirus -- Genus apthovirus -- 13 Family Caliciviridae -- Genome organization -- Virion structure -- General replication cycle -- Attachment/penetration -- Genome replication -- Translation -- Assembly/release -- Diseases -- Acute gastrointestinal disease -- Feline calicivirus -- Rabbit calicivirus -- 14 Family Hepeviridae -- Genome organization -- Virion morphology -- General replication cycle of HEV -- Disease -- References -- 15 Family Astroviridae -- Genome organization -- Virion morphology -- General replication strategy -- Diseases caused by astroviruses -- 16 Family Flaviviridae -- Genome structure/organization -- Virion structure -- General overview of replication -- Protein products -- Diseases -- Hepatitis C -- Diseases caused by members of the genus Flavivirus -- Yellow fever virus -- Dengue fever virus -- Zika virus -- West Nile virus -- Genus Pestivirus -- Diseases caused by members of the genus Pegivirus -- References -- 17 Families Togaviridae and Matonaviridae -- Family Togaviridae -- Genome structure -- Virion structure -- Togavirus replication -- Attachment and penetration -- Translation -- Genome replication -- Assembly and release -- Transmission -- Togaviruses associated with rash and arthritis -- Chikungunya virus -- Other togaviruses of human concern -- Alphaviruses of veterinary importance.
• Family Matonaviridae -- Rubella virus -- Features and general replication cycle -- Disease -- Reference -- 18 Family Coronaviridae -- Coronavirus genome organization -- Virion structure -- Coronavirus structural proteins -- Coronavirus replication cycle -- Attachment -- Penetration -- Amplification -- RNA synthesis -- Assembly and release -- Diseases caused by coronaviruses -- Severe acute respiratory syndrome -- Middle East respiratory syndrome -- Feline coronavirus and feline infectious peritonitis -- Porcine coronaviruses -- Reference -- 19 SARS-CoV-2/COVID-19 -- Genome organization -- Virion and structural proteins -- Nonstructural and accessory proteins -- Overview of replication -- Binding and entry -- Amplification -- Assembly and release -- Origins and pathogenesis of SARS-CoV-2 -- Origins of SARS-CoV-2 -- Route of transmission and target cells -- Disease -- Vaccines -- Treatments -- Viral variation -- Reference -- 20 Family Arteriviridae -- Genome organization -- Virion structure -- Replication cycle -- Diseases caused by arteriviruses -- Equine viral arteritis -- Porcine reproductive and respiratory syndrome -- Simian hemorrhagic fever virus and related viruses -- References -- 21 Family Rhabdoviridae -- Genome organization -- Virus structure -- Overview of replication -- Attachment and penetration -- Transcription and translation -- The switch from mRNA synthesis to genome replication -- Assembly/release -- Diseases -- Rabies and rabies-related viruses -- Chandipura virus -- Vesicular stomatitis virus -- Other rhabdoviruses associated with disease -- 22 Family Paramyxoviridae -- Genome structure/organization -- Virion structure -- Overview of replication -- Attachment and penetration -- Transcription -- Protein synthesis -- Genome replication -- Assembly, release, and maturation -- Diseases -- Measles -- Mumps -- Respiratory tract diseases.
• Canine distemper.
• Description based on print version record.