Details

Autor(en) / Beteiligte

• Torrence, Paul F

Titel

Combating the threat of pandemic influenza : drug discovery approaches

Beschreibungen/Notizen

• Description based upon print version of record.
• Includes bibliographical references and index.
• Existing influenza antivirals : the mechanisms of action and potential in the face of avial influenza / Erik De Clercq -- Development of high-throughput screening assays for influenza / Diana L. Noah, E. Lucile White, and James W. Noah -- Mechanisms of IFN resistance by influenza virus / Heather J. Ezelle and Bret A. Hassel -- Broadly effective anti-respiratory virus agents / Shiro Shigeta -- Current status on development of nucleic acid-based antiviral drugs against influenza virus infection / Jonathan P. Wong ... [et al.] -- Antiviral RNA interferencei strategies targeting influenza virus and other respiratory viruses / Joost Haasnoot and Ben Berkhout -- Promising antiviral glyco-molecules from edible algae / Toshimitsu Hayashi ... [et al.] -- Rational design of an anti-adhesion drug for influenza / Nicolai V. Bovin and Alexandra S. Gambaryan -- Understanding influenza neuraminidase inhibitors using quantitative structure? Activity relationship (QSAR) models / Rajeshwar P. Verma and Corwin Hansch -- Peptide inhibitors targeting virus-cell fusion in Class 1 enveloped viruses / George F. Gao -- Novel approaches to influenza therapeutics / Laura M. Aschenbrenner ... [et a].
• Drug discovery for influenza antiviralsPriorities for combating pandemic influenza include rapid detection and identification, the quick administration of available drugs to treat the infection, the development of new antivirals, and the development of vaccines. Since lead-time may be required to produce an effective vaccine, antivirals would serve as a key first line of defense in containing an outbreak. Diverse antivirals, acting through different mechanisms, would help stay the development of resistant viruses. Thus, drug discovery for influenza antivirals is an important public hea
• English