Details

Autor(en) / Beteiligte

• Biswas, Atanu,

Titel

Statistical advances in the biomedical sciences : clinical trials, epidemiology, survival analysis, and bioinformatics

Auflage

1st ed

Beschreibungen/Notizen

• Description based upon print version of record.
• Includes bibliographical references and index.
• Statistical Advances in the Biomedical Sciences; Contents; Preface; Acknowledgments; Contributors; PART I CLINICAL TRIALS; 1. Phase I Clinical Trials; 1.1 Introduction; 1.2 Phase I Trials in Healthy Volunteers; 1.3 Phase I Trials with Toxic Outcomes Enrolling Patients; 1.3.1 Parametric versus Nonparametric designs; 1.3.2 Markovian-Motivated Up-and-Down Designs; 1.3.3 Isotonic Designs; 1.3.4 Bayesian Designs; 1.3.5 Time-to-Event Design Modifications; 1.4 Other Design Problems in Dose Finding; 1.5 Concluding Remarks; 2. Phase II Clinical Trials; 2.1 Introduction; 2.1.1 Background
• 2.1.2 The Role of Phase II Clinical Trials in Clinical Evaluation of a Novel Therapeutic Agent2.1.3 Phase II Clinical Trial Designs; 2.2 Frequentist Methods in Phase II Clinical Trials; 2.2.1 Review of Frequentist Methods and Their Applications in Phase II Clinical Trials; 2.2.2 Frequentist Methods for Single-Treatment Pilot Studies; 2.2.3 Frequentist Methods for Comparative Studies; 2.2.4 Frequentist Methods for Screening Studies; 2.3 Bayesian Methods in Phase II Clinical Trials; 2.3.1 Review of Bayesian Methods and Their Application in Phase II Clinical Trials
• 2.3.2 Bayesian Methods for Single-Treatment Pilot Studies, Comparative Studies and Selection Screens2.4 Decision-Theoretic Methods in Phase II Clinical Trials; 2.5 Analysis of Multiple Endpoints in Phase II Clinical Trials; 2.6 Outstanding Issues in Phase II Clinical Trials; 3. Response-Adaptive Designs in Phase III Clinical Trials; 3.1 Introduction; 3.2 Adaptive Designs for Binary Treatment Responses; 3.2.1 Play-the-Winner Design; 3.2.2 Randomized Play-the-Winner Design; 3.2.3 Generalized Pólya's Urn (GPU); 3.2.4 Randomized Pólya Urn Design; 3.2.5 Birth-and-Death Urn Design
• 3.2.6 Birth-and-Death Urn with Immigration Design3.2.7 Drop-the-Loser Urn Design; 3.2.8 Sequential Estimation-Adjusted Urn Design; 3.2.9 Doubly Adaptive Biased Coin Design; 3.3 Adaptive Designs for Binary Treatment Responses Incorporating Covariates; 3.3.1 Covariate-Adaptive Randomized Play-the-Winner Design; 3.3.2 Treatment Effect Mappings; 3.3.3 Drop-the-Loser Design with Covariate; 3.4 Adaptive Designs for Categorical Responses; 3.5 Adaptive Designs for Continuous Responses; 3.5.1 Nonparametric-Score-Based Allocation Designs; 3.5.2 Link-Function-Based Allocation Designs
• 3.5.3 Continuous Drop-the-Loser Design3.6 Optimal Adaptive Designs; 3.7 Delayed Responses in Adaptive Designs; 3.8 Biased Coin Designs; 3.9 Real Adaptive Clinical Trials; 3.10 Data Study for Different Adaptive Schemes; 3.10.1 Fluoxetine Trial; 3.10.2 Pregabalin Trial; 3.10.3 Simulated Trial; 3.11 Concluding Remarks; 4. Inverse Sampling for Clinical Trials: A Brief Review of Theory and Practice; 4.1 Introduction; 4.1.1 Inverse Binomial Sampling; 4.1.2 Partial Sequential Sampling; 4.2 Two-Sample Randomized Inverse Sampling for Clinical Trials; 4.2.1 Use of Mann-Whitney Statistics
• 4.2.2 Fixed-Width Confidence Interval Estimation
• The Most Comprehensive and Cutting-Edge Guide to Statistical Applications in Biomedical Research With the increasing use of biotechnology in medical research and the sophisticated advances in computing, it has become essential for practitioners in the biomedical sciences to be fully educated on the role statistics plays in ensuring the accurate analysis of research findings. Statistical Advances in the Biomedical Sciences explores the growing value of statistical knowledge in the management and comprehension of medical research and, more specifically, provides an accessible introduction to t
• English