Details

Autor(en) / Beteiligte

• Sale, Alessandro,

Titel

Environmental experience and plasticity of the developing brain

Ort / Verlag

Hoboken, New Jersey : Wiley,

Erscheinungsjahr

2016

Link zum Volltext

• Wiley Online Library - AutoHoldings Books

Beschreibungen/Notizen

• Description based upon print version of record.
• Includes bibliographical references at the end of each chapters and index.
• Dedication; Title Page; Copyright; Table of Contents; List of contributors; Chapter 1: Environmental enrichment and brain development; Introduction: critical periods and experience-dependent plasticity in brain circuits; Optimization of environmental stimulation: environmental enrichment; Environmental enrichment and visual system development; Concluding remarks; References; Chapter 2: Epigenetic control of visual cortex development and plasticity; Introduction; Overview of chromatin modifications; Epigenetics and brain plasticity; Epigenetic control on visual system development
• Future directionsAcknowledgments; References; Chapter 3: Gene-environment interactions in the etiology of psychiatric and neurodevelopmental disorders; How animal models help us study human brain disorders; Genetic models for complex brain diseases; Behavioral outcomes from environmental modulation; Components of environmental enrichment; Molecular changes in response to environmental modulation; Environment, BDNF, stress, and depression; Epigenetics and environmental influence; Overview of Rett syndrome; Genetic sources of phenotypic variation in Rett syndrome and other brain disorders
• The functions of MeCP2Can disease progression in Rett syndrome be prevented?; Regulation of Bdnf and Crh by MeCP2; Effects of environmental enrichment in Mecp2 mutant mice; Summary; References; Chapter 4: Critical periods and neurodevelopmental brain disorders; Introduction; Developmental aspects of NDDs; Brain development and critical periods; Dysregulation of brain development in NDDs: a framework for misregulated timing; Potential mechanisms underlying critical period dysregulation in NDDs; Corrective strategies for NDDs: genetic and pharmacological interventions
• Syndrome-specific molecules or common signalling hubs? Targets for future pharmacotherapeutic interventionsDysregulated critical period framework as a unifying hypothesis for prominent NDD theories; Implications of misregulated critical periods and future directions; Acknowledgments; References; Chapter 5: Maternal care and DNA methylation; Introduction; DNA methylation; DNA methylation and regulation of gene expression; Reversibility of DNA methylation; DNA methylation changes triggered by differences in maternal care in the nr3c1 gene
• Molecular conduit between experience and DNA: signaling cascade leading from maternal care to epigenetic programmingReversibility of epigenetic programming by maternal care; Epigenetic programming by early life experience in humans; rRNA genes are hypermethylated in suicide victims who were abused as children; The response to early life adversity is broad and involves several gene networks; System-wide responses to maternal deprivation; the impact of rearing differences in nonhuman primates; Natural disasters as a model to study the impact of maternal stress on child DNA methylation
• Summary
• "Environmental Experience and Plasticity of the Developing Brain goes beyond the genetic basis of neurodevelopment. Chapters illuminate the external factors that can dramatically impact the brain early in life and, consequently, the eventual accomplishment of developmental milestones and the construction of adult behavior and personality. Authored and edited by leaders in this rapidly growing field, Environmental Experience and Plasticity of the Developing Brain not only surveys preexisting literature on the effects of environment versus genetics, but also discusses more recent studies on the impacts of neurodevelopment in terms of maternal stimulation, environmental enrichment and sensory deprivation. The book also includes key examples of environmental impacts on preexisting genetic syndromes leading to developmental disabilities. Focus is also given to the consequences of early adverse experience in primates, as well as neurobiological and behavioral consequences in institutionalized human children and the reversibility of such consequences. Environmental Experience and Plasticity of the Developing Brain encompasses a broad area of research in the field of developmental neurobiology and offers a unique combination of different examples of environmental factors affecting brain development and behavior"--Provided by publisher.
• English
• Description based on print version record.