Details

Autor(en) / Beteiligte

• Dasgupta, Amitava,

Titel

Therapeutic drug monitoring : newer drugs and biomarkers [electronic resource]

Auflage

1st ed

Link zum Volltext

• Elsevier Books AutoHoldings

Beschreibungen/Notizen

• Description based upon print version of record.
• Includes bibliographical references and index.
• Front Cover; Therapeutic Drug Monitoring: Newer Drugs and Biomarkers; Copyright; Dedicaction; Contents; Preface; Contributors; Chapter 1 - Introduction to Therapeutic Drug Monitoring; INTRODUCTION; DRUGS THAT REQUIRE THERAPEUTIC DRUG MONITORING; BENEFITS OF THERAPEUTIC DRUG MONITORING; PATHOPHYSIOLOGICAL CONDITIONS AND OTHER FACTORS THAT AFFECT DRUG CONCENTRATIONS; THERAPEUTIC DRUG MONITORING OF VARIOUS DRUG CLASSES; CONCLUSIONS; References; Chapter 2 - Effects of Pre-analytical Variables in Therapeutic Drug Monitoring; INTRODUCTION; SPECIMEN TYPE
• FACTORS THAT AFFECT THERAPEUTIC DRUG MONITORING RESULTSPROTEIN BINDING ALTERATION: IN VIVO AND IN VITRO; SPECIMEN COLLECTION SITE; VOLUME OF SPECIMEN COLLECTED; GLASS VERSUS PLASTIC TUBES FOR COLLECTION OF BLOOD; SERUM VERSUS PLASMA SPECIMEN FOR THERAPEUTIC DRUG MONITORING; SUITABILITY OF SERUM SEPARATOR COLLECTION TUBES FOR SPECIMEN COLLECTION FOR DRUG MONITORING; SAMPLE PREPARATION STEPS; CONCLUSIONS; References; Chapter 3 - Analytical Techniques used in Therapeutic Drug Monitoring; INTRODUCTION; A GENERAL CLASSIFICATION OF ANALYTICAL METHODS
• UNDERSTANDING AND MINIMIZING MEASUREMENT UNCERTAINTY IN THE CLINICAL LABORATORYIMMUNOASSAYS; GAS AND LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY AND LC-MS/MS APPLICATION TO TDM; CONCLUSIONS; References; Chapter 4 - Clinical Utility of Free Drug Monitoring; INTRODUCTION; FREE CONCENTRATIONS VERSUS TOTAL CONCENTRATIONS; PHARMACOKINETIC CONSEQUENCES OF DRUG-PROTEIN BINDING; MONITORING FREE CONCENTRATIONS OF CLASSICAL ANTI-EPILEPTICS; MONITORING FREE CONCENTRATIONS OF ANTIBIOTICS, ANTIMALARIALS AND ANTIRETROVIRALS; MONITORING FREE CONCENTRATIONS OF IMMUNOSUPPRESSANTS
• MONITORING FREE CONCENTRATIONS OF OTHER DRUGSAPPLICATIONS AND METHODS FOR MONITORING FREE DRUG CONCENTRATIONS; ALTERNATIVE METHODS; CONCLUSIONS; References; Chapter 5 - Current Practice of Therapeutic Drug Monitoring; INTRODUCTION; BAYESIAN ESTIMATION; EXAMPLES OF CLINICAL TRANSFERABILITY; CONCLUSION; References; Chapter 6 - An Introduction to Personalized Medicine; INTRODUCTION; OVERVIEW OF CLASSICAL SEQUENCE VARIATION PROFILING TECHNIQUES; RECENT MOLECULAR PROFILING TECHNOLOGIES; SELECT BIOMARKERS IN PHARMACOGENOMICS
• TRANSLATIONAL APPROACHES ASSOCIATED WITH PHARMACOGENOMICS AND PERSONALIZED MEDICINECONCLUSIONS; References; Chapter 7 - Application of Ultra-High Throughput Sequencing and Microarray Technologies in Pharmacogenomics Testing; INTRODUCTION; DNA MICROARRAY; PHARMACOGENETIC TESTING AND HEALTHCARE; DNA MICROARRAY PLATFORMS; MICROARRAYS AND GENOTYPE; MICROARRAYS IN CLINICAL DIAGNOSIS; SEQUENCING TECHNOLOGIES - THE FIRST GENERATION; SEQUENCING TECHNOLOGIES - NEXT GENERATION; EXON CAPTURE AND OLIGONUCLEOTIDE-BASED GENOMIC SELECTION; MICROARRAY TECHNOLOGY VERSUS DEEP SEQUENCING
• SEQUENCING AND IMPLICATIONS FOR PHARMACOGENOMICS TESTING
• Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, to
• English