Details

Autor(en) / Beteiligte

• Holland, I. B

Titel

ABC proteins : from bacteria to man [electronic resource]

Auflage

1st ed

Link zum Volltext

• Elsevier Books AutoHoldings

Beschreibungen/Notizen

• Description based upon print version of record.
• Includes bibliographical references and index.
• Cover; CONTENTS; CONTRIBUTORS; ABC Transporters: an Introduction and Overview; INTRODUCTION; TRANSPORT ACROSS CELL MEMBRANES; SUBSTRATE SPECIFICITY AND PHYSIOLOGICAL ROLES; DOMAIN ORGANIZATION AND STRUCTURE; STRUCTURES AND MECHANISMS OF TRANSPORT; CONCLUSIONS; REFERENCES; PART I PHYLOGENY AND EVOLUTION OF ABC TRANSPORTERS; Chapter 1 Phylogenetic and Functional Classification of ABC (ATP-binding Cassette) Systems; INTRODUCTION; INVENTORY AND CLASSIFICATION OF ABC SYSTEMS; FAMILIES OF ABC SYSTEMS IN LIVING ORGANISMS
• CLASS 1 COMPRISES ESSENTIALLY ALL KNOWN EXPORTERS WITH FUSED ABC AND IM DOMAINSThe FAE (ABCD) family putatively involved in very long chain fatty acid export; The DPL family involved in drug, peptide and lipid export; The LAE subfamily involved in lantibiotic export; The BAE subfamily involved in bacteriocin and competence peptide export; The CYD subfamily putatively implicated in cytochrome bd biogenesis; The HMT subfamily of mitochondrial and bacterial transporters; The CHV family involved in beta-1,2-glucan export; The MDL subfamily of mitochondrial and bacterial transporters
• The SID subfamilyThe LIP subfamily involved in the export of the lipid A moiety of lipopolysaccharide; The PED subfamily involved in prokaryote drug export; The LLP subfamily of LIP-like exporters of unknown function; The ARP family involved in production of or resistance to antibiotics; The PRT subfamily involved in export of hydrolytic enzymes and S-layer proteins; The HLY subfamily involved in RTX toxin export; The TAP subfamily involved in eukaryote peptide export; The Pgp subfamily involved in eukaryote multiple drug resistance and lipid export
• The OAD family involved in organic anion and conjugate drug export and in ion channel regulationThe CFTR subfamily of anion selective channels; The MRP family involved in conjugate drug resistance; The SUR subfamily of potassium channel regulators; The EPD family involved in eye pigment precursor transport, lipid transport regulation and drug resistance; The WHI subfamily; The PDR subfamily involved in pleiotropic drug resistance; The CCM family involved in bacterial cytochrome c biogenesis; The MCM family
• CLASS 2 CONTAINS SYSTEMS WITH NO KNOWN IM DOMAINS AND INVOLVED IN ANTIBIOTIC RESISTANCE AND CELLULAR PROCESSES OTHER THAN TRANSPORTThe RLI family; The ART family of systems involved in antibiotic resistance and in translation of mRNA and its regulation; The EF-3 subfamily; The REG subfamily of proteins involved in the regulation of diverse phenomena; The ARE subfamily of antibiotic resistance determinants in prokaryotes; The UVR family involved in DNA repair and drug resistance; CLASS 3 CONTAINS SYSTEMS WITH UNFUSED IM AND ABC DOMAINS COMPRISING ALL KNOWN BPD TRANSPORTERS AND MORE
• The MET family specific for metallic cations
• ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated.Key Features* Phylogeny and Evoloution of ABC Transporters* Fundamental Aspects of the Mechanism of Action of ABC Transporters* Prokaryote ABC Transporters* Non
• English