Details

Autor(en) / Beteiligte

• Hodgson, Ernest

Titel

Pesticide biotransformation and disposition [electronic resource]

Auflage

1st ed

Link zum Volltext

• Elsevier Books AutoHoldings

Beschreibungen/Notizen

• Description based upon print version of record.
• Includes bibliographical references and index.
• Front Cover; Pesticide Biotransformation and Disposition; Copyright Page; Contents; Dedication from Hayes' Handbook of Pesticide Toxicology, Third Edition; Preface; Preface from Hayes' Handbook of Pesticide Toxicology, Third Edition; Contributing Authors; 1 Introduction to Pesticide Biotransformation and Disposition; Introduction; Relevance of Biotransformation and Disposition Studies; References; 2 Summary of Methods Used in the Study of Pesticide Biotransformation and Disposition; Introduction; Analytical Methods for Pesticides and Pesticide Metabolites; Sampling; Blood; Urine and Bile
• TissueOther Methods; Sample Extraction, Cleanup, and Enrichment; Thin-Layer Chromatography; Column Adsorption: Hydrophobic and Affinity; Size-Exclusion Chromatography; Enrichment; Analysis; Gas Chromatography; High-Performance Liquid Chromatography; Capillary Electrophoresis (CE); Mass Spectroscopy; Uptake, Distribution, and Toxicokinetics; Cell Culture, Subcellular Fractions, and Recombinant Enzymes; Proteomics; Metabolomics; Summary; References; 3 Absorption; Introduction; Factors that Influence the Transfer and Availability of Chemicals in the Body; Properties of Cell Membranes
• Transport MechanismsPassive Transport; Specialized Transport; Protein (Macromolecular) Binding; Absorption; Percutaneous Absorption; Anatomical Site Differences; Pesticide Formulation and Mixtures; Environmental Factors; (a) Temperature; (b) Humidity and Occlusion; (c) Soil; Absorption from the Gastrointestinal Tract; Absorption from the Respiratory Tract; Absorption after Exposure by Other Routes; Summary and Future Directions; References; 4 Introduction to Biotransformation (Metabolism); Introduction; Reactions Catalyzed in Xenobiotic Metabolism; Xenobiotic-Metabolizing Enzymes
• Phase I Xenobiotic-Metabolizing EnzymesCytochrome P450 Monooxygenases; Flavin-Containing Monooxygenase; Other Phase I Enzymes; Epoxide Hydrolases; Prostaglandin Synthetase; Aldehyde Oxidase; Hydrolases and Amidases; DDT Dehydrochlorinase; Phase II Xenobiotic-Metabolizing Enzymes; Glutathione S-Transferases; Glucuronyl Transferases; Sulfotransferases; Other Phase II Enzymes; Methyltransferases; Cysteine Conjugate ß-Lyase; Acylation; Phosphate Conjugation; Summary and Conclusions; References; 5 Biotransformation (Metabolism) of Pesticides; Introduction; External Transformation
• BiotransformationBiotransformation in the Liver; CYP and FMO Monooxygenation; Other Phase I Enzymes; Phase II Enzymes; Comparative Aspects; Biotransformation in Extrahepatic Tissues; Lung; Nasal Tissues; Skin; Kidney; Central Nervous System; Gastrointestinal Tract; Metabolism in Humans; Toxicity of Metabolites; Physiological Factors Affecting Biotransformation; Developmental Effects; Species Differences; Individual and Strain Differences; Gender Differences; Genetic Factors; Tolerance and Resistance; Tolerance; Resistance; Conclusions; References; Further Reading
• 6 Distribution and Pharmacokinetics Models
• Biotransformation of Pesticides is an updated, ""one-stop"" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and huma
• English