Details

Autor(en) / Beteiligte

• Orwoll, Eric S
• Bilezikian, John P
• Vanderschueren, Dirk

Titel

Osteoporosis in men : the effects of gender on skeletal health

Auflage

2nd edition

Ort / Verlag

Amsterdam ; : Elsevier/Academic Press,

Erscheinungsjahr

©2010

Link zum Volltext

• Elsevier Books AutoHoldings

Verknüpfte Titel

Beschreibungen/Notizen

• Description based upon print version of record.
• Front Cover -- Osteoporosis in Men: The Effects of Gender on Skeletal Health -- Copyright Page -- Contents -- Contributors -- Foreword -- Preface -- SECTION 1 Essentials of Bone Biology -- CHAPTER 1 The Biochemistry of Bone: Composition and Organization -- INTRODUCTION -- BONE ORGANIZATION -- BONE COMPOSITION: THE BONE COMPOSITE -- HOW BONES CHANGE WITH AGE -- ACKNOWLEDGMENTS -- References -- CHAPTER 2 Bone Remodeling: Cellular Activities in Bone -- INTRODUCTION -- CELLULAR MECHANISM OF BONE REMODELING -- PHYSIOLOGICAL FUNCTIONS OF BONE REMODELING -- VARIATION IN BONE REMODELING ACTIVITY THROUGHOUT THE SKELETON -- References -- CHAPTER 3 Assessment of Bone Turnover in Men Using Biochemical Markers -- INTRODUCTION -- NEW BIOCHEMICAL MARKERS OF BONE METABOLISM AND NEW ASSAYS -- NEW TECHNOLOGIES FOR DISCOVERY AND ASSAY BONE MARKERS -- FACTORS INFLUENCING BTM LEVELS IN MEN -- CLINICAL APPLICATIONS OF BONE TURNOVER MARKERS IN MALE OSTEOPOROSIS -- EFFECT OF ANTI-OSTEOPOROTIC TREATMENT ON BTM IN MEN -- CONCLUSION -- References -- CHAPTER 4 Fundamentals of Mineral Homeostasis -- INTRODUCTION -- TOTAL BODY STORES OF ESSENTIAL MINERALS -- EXTRACELLULAR MINERAL METABOLISM - CIRCULATING LEVELS -- INTRACELLULAR MINERAL METABOLISM -- MINERAL ION BALANCE -- SUMMARY -- References -- CHAPTER 5 The Mechanical Properties of Bone -- INTRODUCTION -- THE IDEA OF HIERARCHY IN BONE MECHANICS -- ANATOMICAL STRUCTURAL EFFECT -- ULTRASTRUCTURE AND MICROSTRUCTURE AND EFFECTS ON MECHANICAL PROPERTIES -- ULTRASTRUCTURE AND BONE MECHANICAL PROPERTIES -- STRAIN RATE, FRACTURE PROPAGATION TOUGHNESS AND FATIGUE -- THE COMPLETE DEPENDENCE ON DAMAGE REPAIR FOR MECHANICAL FUNCTION -- References -- CHAPTER 6 Essentials of Bone Biology: Assessment of Bone Architecture -- INTRODUCTION -- DXA AND RADIOGRAPHIC IMAGING -- COMPUTED TOMOGRAPHY (CT).
• ASSESSMENT OF BONE MINERAL DENSITY: QUANTITATIVE COMPUTED TOMOGRAPHY (QCT) -- MEASUREMENT OF STRUCTURE AND BMD USING VOLUMETRIC CT IMAGES OF THE SPINE AND HIP -- FINDINGS BASED ON VOLUMETRIC QCT ANALYSES -- 3D QCT OF THE VERTEBRAE -- FINITE ELEMENT MODELING (FEM) -- MICROCT METHODS -- CONCLUSION -- References -- SECTION 2 Development and Growth of the Male Skeleton -- CHAPTER 7 Skeletal Growth in Males -- INTRODUCTION -- GROWTH IN STATURE -- GROWTH IN BONE STRUCTURE -- SKELETAL FRAGILITY HAS ITS ORIGIN EARLY IN LIFE -- MODELING AND REMODELING - MACHINERY OF TRACKING -- BONE GROWTH AND GH-IGF-I/SEX HORMONES -- SUMMARY -- References -- CHAPTER 8 Pubertal Growth of the Male Skeleton -- INTRODUCTION -- SKELETAL MATURATION -- BONE MEASUREMENT TECHNIQUES IN CHILDREN -- SKELETAL CHANGES DURING PUBERTY -- PEAK BONE MASS -- CONCLUSION -- References -- CHAPTER 9 The Effects of Sex Steroids on Bone Growth -- INTRODUCTION -- LONGITUDINAL AND RADIAL BONE GROWTH -- BONE MASS ACQUISITION DURING CHILDHOOD AND ADOLESCENCE -- CHANGES IN BONE SIZE BY PERIOSTEAL EXPANSION DURING GROWTH -- RELEVANT CLINICAL OBSERVATIONS ON THE SEX STEROIDS' EFFECT ON BONE GROWTH -- CONCLUSIONS -- References -- CHAPTER 10 Nutritional Basis of Skeletal Growth -- INTRODUCTION -- ASSESSING THE ROLE OF NUTRITION IN SKELETAL ACQUISITION -- RELATIVE ROLE OF NUTRITION IN SKELETAL REQUISITION -- MICRONUTRIENTS AND BONE GROWTH -- DIETARY PATTERNS AND BONE GROWTH -- DIET AND EXERCISE INTERACTIONS -- NUTRITION AND PEDIATRIC DISORDERS -- CONCLUSIONS -- References -- CHAPTER 11 Physical Activity and Skeletal Growth -- INTRODUCTION -- HOW DOES BONE ADAPT TO PHYSICAL ACTIVITY? -- HOW TO MEASURE BONE ADAPTATION TO PHYSICAL ACTIVITY -- WHAT TYPES OF PHYSICAL ACTIVITY PROMOTE BONE STRENGTH? -- HOW DOES PHYSICAL ACTIVITY INFLUENCE THE NORMAL PATTERN OF BONE ACCRUAL IN BOYS?.
• WHAT HAVE WE LEARNED FROM CROSS-SECTIONAL STUDIES? -- PROSPECTIVE OBSERVATIONAL STUDIES -- WHAT HAVE WE LEARNED FROM EXERCISE INTERVENTION STUDIES? -- DO THE BENEFITS OF PHYSICAL ACTIVITY PERSIST? -- SUMMARY AND CONCLUSION -- References -- SECTION 3 Skeletal Genetics -- CHAPTER 12 The Genetics of Peak Bone Mass -- INTRODUCTION -- LINKAGE STUDIES -- ASSOCIATION STUDIES -- ANIMAL STUDIES -- References -- SECTION 4 Aging and the Male Skeleton -- CHAPTER 13 Age-related Changes in Bone Remodeling and Microarchitecture -- INTRODUCTION -- THE PROCESS AND PURPOSE OF BONE MODELING AND REMODELING -- ABNORMALITIES IN BONE REMODELING DURING AGING -- BONE LOSS DURING YOUNG ADULTHOOD, MENOPAUSE AND ADVANCED AGE -- REDUCED PERIOSTEAL BONE FORMATION IN ADULTHOOD -- SEX DIFFERENCES IN TRABECULAR AND CORTICAL BONE LOSS AND FRACTURE RATES -- SUMMARY AND CONCLUSION -- References -- CHAPTER 14 Markers of Bone Remodeling and the Aging Skeleton -- INTRODUCTION -- AGE-RELATED CHANGES IN BONE MARKER LEVELS -- BONE MARKERS, BONE LOSS AND FRACTURE RISK IN AGING MEN -- THE RESPONSE OF BONE TURNOVER MARKERS TO PHARMACOLOGICAL INTERVENTIONS IN AGING MEN -- CONCLUSION -- References -- CHAPTER 15 Alterations in Mineral Metabolism in the Aging Male -- INTRODUCTION -- CELLULAR CHANGES -- AGE-RELATED HORMONAL CHANGES IN MINERAL METABOLISM -- SUMMARY -- References -- CHAPTER 16 Changes in Bone Size and Geometry with Aging -- RADIAL BONE GROWTH IN CHILDREN AND ADOLESCENTS -- RADIAL BONE GROWTH DURING AGING -- DETERMINANTS OF THE BONE SIZE AND AGE-RELATED CHANGES IN BONE GEOMETRY -- AGE-RELATED CHANGES IN BONE SHAPE -- WHY DO BONES GROW IN WIDTH AFTER CESSATION OF THE GROWTH IN LENGTH? -- METHODOLOGICAL LIMITATIONS OF THE STUDIES ON THE AGE-RELATED CHANGES IN BONE SIZE -- GENERAL CONCLUSIONS -- ACKNOWLEDGMENTS -- References -- CHAPTER 17 Aging and Bone Loss -- INTRODUCTION.
• UNDERSTANDING BONE LOSS WITH AGING IN MEN -- QUANTIFYING BONE LOSS IN MEN -- BONE LOSS WITH AGING IN MEN -- FACTORS CONTRIBUTING TO BONE LOSS -- PRACTICAL SCREENING FOR SIGNIFICANT MALE BONE LOSS AND OSTEOPOROSIS -- SUMMARY -- References -- CHAPTER 18 The Effect of Age on Material Properties -- INTRODUCTION -- BIOMECHANICAL MATERIAL PROPERTIES OF THE SKELETON -- CHANGES TO BIOMECHANICAL MATERIAL PROPERTIES WITH AGE -- MINERAL EFFECTS IN AGE-RELATED MATERIAL PROPERTY ALTERATIONS -- COLLAGEN EFFECTS IN AGE-RELATED MATERIAL PROPERTY ALTERATIONS -- MICRODAMAGE EFFECTS IN AGE-RELATED MATERIAL PROPERTY ALTERATIONS -- CONCLUSIONS -- References -- SECTION 5 Nutritional Issues -- CHAPTER 19 Calcium, Bone Strength and Fractures -- INTRODUCTION -- CALCIUM PHYSIOLOGY -- CALCIUM REQUIREMENTS -- CALCIUM AND BONE STRENGTH -- EVIDENCE OF CALCIUM'S EFFECT ON BMD IN ADULTS -- CALCIUM AND FRACTURES -- CHILDREN AND CALCIUM -- CONCLUSION -- References -- CHAPTER 20 Vitamin D and Bone -- INTRODUCTION -- ORIGIN, METABOLISM, ACTION AND MODE OF ACTION -- VITAMIN D AND BONE: BASIC MECHANISMS -- VITAMIN D AND BONE: CLINICAL ASPECTS -- SURROGATE ENDPOINTS -- HARD ENDPOINTS -- CHOICE OF VITAMIN D PRODUCT AND TREATMENT REGIMEN -- OPTIMAL VITAMIN D STATUS VERSUS PRESENT WORLD REALITY -- References -- CHAPTER 21 Role of Dietary Protein in Bone Growth and Bone Loss -- INTRODUCTION -- DIETARY PROTEIN AND BONE GROWTH -- DAIRY PRODUCTS AND BONE GROWTH -- DIETARY PROTEIN AND BONE MINERAL MASS -- DIETARY PROTEIN AND FRACTURE RISK -- DIETARY PROTEIN AND BONE METABOLISM -- EFFECTS OF PROTEIN INSUFFICIENCY CORRECTION -- ACKNOWLEDGMENT -- References -- SECTION 6 Sex Steroids and the Skeleton in Men -- CHAPTER 22 The Molecular Biology of Sex Steroids in Bone: Similarities and Differences among the Sexes -- INTRODUCTION -- GENERAL ASPECTS OF THE MECHANISMS OF SEX STEROID ACTION IN BONE CELLS.
• ESTROGEN AND ANDROGENS CONTROL OSTEOBLASTOGENESIS AND OSTEOCLASTOGENESIS -- ESTROGEN AND ANDROGENS CONTROL BONE CELL SURVIVAL -- OXIDATIVE STRESS AND THE CONTROL OF BONE MASS -- ESTROGEN RECEPTOR SIGNALING AND MECHANOTRANSDUCTION -- EFFECTS ON THE PERIOSTEUM -- T CELLS AND THE REGULATION OF BONE RESORPTION -- ER AND AR KNOCKOUT MODELS -- References -- CHAPTER 23 Estrogen and the Skeleton - Rodents -- INTRODUCTION -- ESTROGENS AND BONE GROWTH IN MALES -- ESTROGENS AND BONE MAINTENANCE IN MALES -- References -- CHAPTER 24 Estrogen and the Skeleton - Humans -- INTRODUCTION -- ESTROGEN AND BONE GROWTH IN MEN -- ESTROGEN AND BONE MAINTENANCE IN MEN -- ESTROGEN AND FRACTURES IN MEN -- References -- CHAPTER 25 Androgens and Bone: Basic Aspects -- INTRODUCTION -- ANDROGENS AND THE ROLE OF ANDROGEN METABOLISM IN BONE -- DHT -- MECHANISMS OF ANDROGEN ACTION IN BONE: THE ANDROGEN RECEPTOR -- MOLECULAR MECHANISMS OF ANDROGEN ACTION IN BONE CELLS: THE AR -- LOCALIZATION OF AR EXPRESSION IN OSTEOBLASTIC POPULATIONS -- REGULATION OF AR EXPRESSION -- EFFECTS OF ANDROGENS ON THE PROLIFERATION AND DIFFERENTIATION OF OSTEOBLASTIC CELLS -- ANDROGEN EFFECTS ON OSTEOCLASTS AND OTHER CELLS -- ANDROGEN EFFECTS ON BONE: ANIMAL STUDIES -- EFFECTS ON BONE GROWTH DURING SKELETAL DEVELOPMENT -- EFFECTS ON EPIPHYSEAL FUNCTION DURING DEVELOPMENT -- EFFECTS ON BONE MASS IN GROWING MALE ANIMALS: ANIMAL MODELS OF ALTERED ANDROGEN RESPONSIVENESS -- EFFECTS ON THE PERIOSTEUM: THE ROLE OF AR VERSUS AROMATIZATION OF TESTOSTERONE -- EFFECTS ON BONE MASS IN ADULTS: EFFECTS OF CASTRATION IN YOUNG AND ADULT ANIMALS -- ANDROGENS IN THE FEMALE ANIMAL -- EFFECTS OF REPLACEMENT SEX STEROIDS AFTER CASTRATION -- SUMMARY -- References -- CHAPTER 26 Androgens and the Skeleton - Humans -- INTRODUCTION -- ANDROGENS AND BONE METABOLISM IN NORMAL MEN.
• BONE MINERAL DENSITY IN MEN WITH HYPOGONADISM OR OTHER DISORDERS OF ANDROGEN ACTION.
• Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men. This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger - 8.5 x 11. This edition  of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy. Brings together more eminent investigators and clinicians to interpret developments in this growing field. Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy. There is no book on the market that covers osteoporosis in men as comprehensively as this book.
• English
• Description based on publisher supplied metadata and other sources.