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Front Cover; Growth Hormone Secretagogues: Basic Findings and Clinical Implications; Copyright Page; Prologue; Contents; Contributing Authors; Chapter 1. Introduction; Chapter 2. GHRP: Unnatural Toward the Natural; Chapter 3. Impervious Peptides as GH Secretagogues; Chapter 4. GHRP Structure-Activity Relationship: An In Vivo Perspective; Chapter 5. Molecular Analysis of the Growth Hormone Secretagogue Receptor; Chapter 6. Intracellular GHRP Signalling; Chapter 7. The Effects of GH-Secretagogues on Human Pituitary Cells in Culture and on Rat Hypothalamic Tissue
Chapter 8. Hypothalamic Site and Mechanism of Action of Growth Hormone SecretagoguesChapter 9. Mechanisms of Actions of Growth Hormone-Releasing Peptides and their Analogues In Vivo; Chapter 10. Animal Models of Growth Hormone Deficiency as Tools to Study Growth Hormone Releasing Mechanisms; Chapter 11. Regulation of Growth Hormone (GH) Pulsatility in Humans; Chapter 12. Hormonal Activities of Growth Hormone Secretagogues (GHS) Across Human Lifespan; Chapter 13. Effectiveness of Growth Hormone Secretagogues in the Diagnosis and Treatment of GH Secretory Deficiency
Chapter 14. Does Desensitisation to Growth Hormone Secretagogues Occur?Chapter 15. GHRPs in Human Obesity; Chapter 16. Effects of Growth Hormone Secretagogues on in vivo Substrate Metabolism in Humans; Chapter 17. Growth Hormone Secretagogues. Physiological Role and Clinical Implications; Chapter 18. Growth Hormone Secretagogues in Critical Illness; Chapter 19. Growth Hormone Secretagogues in Catabolic Illness; Chapter 20. Treatment of Children with Short Stature by Growth Hormone Secretagogues; Chapter 21. Therapeutic Potential of GH Secretagogues in Adults
Chapter 22. Growth Hormone Secretagogue Influences Feeding Behaviour in Experimental AnimalsChapter 23. Growth Hormone Secretagogues and Sleep; Chapter 24. Hexarelin, A Synthetic Growth Hormone Secretagogue, Exhibits Protectant Activity in Experimental Myocardial lschemia and Reperfusion; Chapter 25. Potential Applications of Growth Hormone Secretagogues; Index
Growth hormone secretagogues (GHS) administered alone or in combination with growth hormone releasing hexapeptides, are effective probes for the diagnosis of GH deficiency in both children and adults. Current research has developed and tested different GHS compounds that are active by the oral route, and have improved potency and bioavailability, giving rise to exciting therapeutic possibilities. There was an enthusiastic response from experts in this area to the idea of distilling the huge amount of available data into one multi-authored volume. Each contributor has advanced the field o