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Proton channels and exchangers in cancer

Biochimica et biophysica acta, 2015-10, Vol.1848 (10), p.2715-2726

2015

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Na+/H+ antiporter (NHE1) and lactate/H+ symporters (MCTs) in pH homeostasis and cancer metabolism

Biochimica et biophysica acta, 2016-10, Vol.1863 (10), p.2465-2480

2016

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Cortisol regulates Na+ uptake in zebrafish, Danio rerio, larvae via the glucocorticoid receptor

Molecular and cellular endocrinology, 2012-11, Vol.364 (1-2), p.113-125

2012

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Ammonia excretion via Rhcg1 facilitates Na⁺ uptake in larval zebrafish, Danio rerio, in acidic water

American journal of physiology. Regulatory, integrative and comparative physiology, 2011-11, Vol.301 (5), p.R1517-R1528

2011

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pH sensing by FAK-His58 regulates focal adhesion remodeling

The Journal of cell biology, 2013-09, Vol.202 (6), p.849-859

2013

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KR-33028, a potent inhibitor of the Na+/H+ exchanger NHE1, suppresses metastatic potential of triple-negative breast cancer cells

Biochemical pharmacology, 2016-10, Vol.118, p.31-39

2016

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Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research

Journal of translational medicine, 2013-11, Vol.11 (1), p.282-282

2013

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Na+-H+ exchanger, pH regulation and cancer

Recent patents on anti-cancer drug discovery, 2013-01, Vol.8 (1), p.85

2013

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Activation of Na+/H+ Exchanger 1 Is Sufficient to Generate Ca2+ Signals That Induce Cardiac Hypertrophy and Heart Failure

Circulation research, 2008-10, Vol.103 (8), p.891-899

2008

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The Na+/H+-exchanger (NHE1) generates pH nanodomains at focal adhesions

Journal of cellular physiology, 2013-06, Vol.228 (6), p.1351-1358

2013

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DJ‐1/Park7 Sensitive Na+/H+ Exchanger 1 (NHE1) in CD4+ T Cells

Journal of cellular physiology, 2017-11, Vol.232 (11), p.3050-3059

2017

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Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters

American Journal of Physiology: Cell Physiology, 2009-03, Vol.296 (3), p.C570-C582

2009

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CD44 Interaction with Na+-H+ Exchanger (NHE1) Creates Acidic Microenvironments Leading to Hyaluronidase-2 and Cathepsin B Activation and Breast Tumor Cell Invasion

The Journal of biological chemistry, 2004-06, Vol.279 (26), p.26991-27007

2004

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Protease activity at invadopodial focal digestive areas is dependent on NHE1-driven acidic pHe

Oncology reports, 2014-02, Vol.31 (2), p.940-946

2014

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Furosemide-induced urinary acidification is caused by pronounced H+ secretion in the thick ascending limb

American journal of physiology. Renal physiology, 2015-07, Vol.309 (2), p.F146-F153

2015

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Molecular transport machinery involved in orchestrating luminal acid‐induced duodenal bicarbonate secretion in vivo

The Journal of physiology, 2013-11, Vol.591 (21), p.5377-5391

2013

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Inhibition of the Sodium-Proton Antiporter (Exchanger) is a Plausible Mechanism of Potential Benefit and Harm for Drugs Designed to Block Sodium Glucose Co-transporter 2

Reviews in cardiovascular medicine, 2018-06, Vol.19 (2), p.51-63

2018

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Anti-proliferative effect of atrial natriuretic peptide on colorectal cancer cells: Evidence for an Akt-mediated cross-talk between NHE-1 activity and Wnt/β-catenin signaling

Biochimica et biophysica acta, 2012-06, Vol.1822 (6), p.1004-1018

2012

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Inhibition of Na+ /H+ exchanger 1 by 5-(N-ethyl-N-isopropyl) amiloride reduces hypoxia-induced hepatocellular carcinoma invasion and motility

Cancer letters, 2010-09, Vol.295 (2), p.198-204

2010

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Membrane androgen receptor sensitive Na+/H+ exchanger activity in prostate cancer cells

FEBS letters, 2014-05, Vol.588 (9), p.1571-1579

2014

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Bactridine 2 effect in DRG neurons. Identification of NHE as a second target

Toxicon (Oxford), 2018-09, Vol.151, p.37-46

2018

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Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy

Circulation (New York, N.Y.), 2007-03, Vol.115 (9), p.1090-1100

2007

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The Intracellular Na+/H+ Exchanger NHE7 Effects a Na+-Coupled, but Not K+-Coupled Proton-Loading Mechanism in Endocytosis

Cell reports (Cambridge), 2014-05, Vol.7 (3), p.689-696

2014

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Sgk1-Dependent Stimulation of Cardiac Na+/H+ Exchanger Nhe1 by Dexamethasone

Cellular physiology and biochemistry, 2013-01, Vol.32 (1), p.25-38

2013

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Extracellular matrix composition and interstitial pH modulate NHE1-mediated melanoma cell motility

International journal of oncology, 2014-01, Vol.44 (1), p.78-90

2014

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Proton channels and exchangers in cancer

Na+/H+ antiporter (NHE1) and lactate/H+ symporters (MCTs) in pH homeostasis and cancer metabolism

Cortisol regulates Na+ uptake in zebrafish, Danio rerio, larvae via the glucocorticoid receptor

Ammonia excretion via Rhcg1 facilitates Na⁺ uptake in larval zebrafish, Danio rerio, in acidic water

pH sensing by FAK-His58 regulates focal adhesion remodeling

KR-33028, a potent inhibitor of the Na+/H+ exchanger NHE1, suppresses metastatic potential of triple-negative breast cancer cells

Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research

Na+-H+ exchanger, pH regulation and cancer

Activation of Na+/H+ Exchanger 1 Is Sufficient to Generate Ca2+ Signals That Induce Cardiac Hypertrophy and Heart Failure

The Na+/H+-exchanger (NHE1) generates pH nanodomains at focal adhesions

DJ‐1/Park7 Sensitive Na+/H+ Exchanger 1 (NHE1) in CD4+ T Cells

Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters

CD44 Interaction with Na+-H+ Exchanger (NHE1) Creates Acidic Microenvironments Leading to Hyaluronidase-2 and Cathepsin B Activation and Breast Tumor Cell Invasion

Protease activity at invadopodial focal digestive areas is dependent on NHE1-driven acidic pHe

Furosemide-induced urinary acidification is caused by pronounced H+ secretion in the thick ascending limb

Molecular transport machinery involved in orchestrating luminal acid‐induced duodenal bicarbonate secretion in vivo

Inhibition of the Sodium-Proton Antiporter (Exchanger) is a Plausible Mechanism of Potential Benefit and Harm for Drugs Designed to Block Sodium Glucose Co-transporter 2

Anti-proliferative effect of atrial natriuretic peptide on colorectal cancer cells: Evidence for an Akt-mediated cross-talk between NHE-1 activity and Wnt/β-catenin signaling

Inhibition of Na+ /H+ exchanger 1 by 5-(N-ethyl-N-isopropyl) amiloride reduces hypoxia-induced hepatocellular carcinoma invasion and motility

Membrane androgen receptor sensitive Na+/H+ exchanger activity in prostate cancer cells

Bactridine 2 effect in DRG neurons. Identification of NHE as a second target

Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy

The Intracellular Na+/H+ Exchanger NHE7 Effects a Na+-Coupled, but Not K+-Coupled Proton-Loading Mechanism in Endocytosis

Sgk1-Dependent Stimulation of Cardiac Na+/H+ Exchanger Nhe1 by Dexamethasone

Extracellular matrix composition and interstitial pH modulate NHE1-mediated melanoma cell motility

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