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Endothelial NADPH oxidases: which NOX to target in vascular disease?

Trends in endocrinology and metabolism, 2014-09, Vol.25 (9), p.452-463

2014

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Nox (NADPH Oxidase) 1, Nox4, and Nox5 Promote Vascular Permeability and Neovascularization in Retinopathy

Hypertension (Dallas, Tex. 1979), 2020-04, Vol.75 (4), p.1091-1101

2020

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Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease

Diabetologia, 2017-05, Vol.60 (5), p.927-937

2017

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Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling

Arteriosclerosis, thrombosis, and vascular biology, 2016-02, Vol.36 (2), p.295-307

2016

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Reactive oxygen species augment contractile responses of saphenous artery in 10-15-day-old but not adult rats: Substantial role of NADPH oxidases

Free radical biology & medicine, 2024-04, Vol.216, p.24-32

2024

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NADPH oxidases in traumatic brain injury – Promising therapeutic targets?

Redox biology, 2018-06, Vol.16, p.285-293

2018

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Differential contribution of Nox1, Nox2 and Nox4 to kidney vascular oxidative stress and endothelial dysfunction in obesity

Redox biology, 2020-01, Vol.28, p.101330, Article 101330

2020

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ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis

American Journal of Physiology: Cell Physiology, 2017-06, Vol.312 (6), p.C749-C764

2017

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Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

PloS one, 2015-07, Vol.10 (7), p.e0129743

2015

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Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice

Nature communications, 2017-12, Vol.8 (1), p.1887-16, Article 1887

2017

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Coordination between NADPH oxidase and vascular peroxidase 1 promotes dysfunctions of endothelial progenitor cells in hypoxia-induced pulmonary hypertensive rats

European journal of pharmacology, 2019-08, Vol.857, p.172459-172459, Article 172459

2019

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Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

Biochemistry (Easton), 2014-08, Vol.53 (31), p.5111-5120

2014

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NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

Brain (London, England : 1878), 2012-03, Vol.135 (Pt 3), p.886-899

2012

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The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

The Journal of biological chemistry, 2011-04, Vol.286 (15), p.13304-13313

2011

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Magnesium isoglycyrrhizinate alleviates fructose-induced liver oxidative stress and inflammatory injury through suppressing NOXs

European journal of pharmacology, 2020-09, Vol.883, p.173314-173314, Article 173314

2020

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Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

Journal of the American Society of Nephrology, 2014-06, Vol.25 (6), p.1237-1254

2014

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Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis

Arteriosclerosis, thrombosis, and vascular biology, 2016-05, Vol.36 (5), p.846-854

2016

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NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

Redox biology, 2014-01, Vol.2 (C), p.267-272

2014

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Therapeutic potential of NADPH oxidase 1/4 inhibitors

British journal of pharmacology, 2017-06, Vol.174 (12), p.1647-1669

2017

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Regulation of Nox and Duox enzymatic activity and expression

Free radical biology & medicine, 2007-08, Vol.43 (3), p.319-331

2007

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Hypoxia-Dependent Regulation of Nonphagocytic NADPH Oxidase Subunit NOX4 in the Pulmonary Vasculature

Circulation research, 2007-08, Vol.101 (3), p.258-267

2007

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New insights in the molecular regulation of the NADPH oxidase 2 activity: Negative modulation by Poldip2

Free radical biology & medicine, 2023-04, Vol.199, p.113-125

2023

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Role of NADPH oxidase isoforms NOX1, NOX2 and NOX4 in myocardial ischemia/reperfusion injury

Journal of molecular and cellular cardiology, 2013-11, Vol.64, p.99-107

2013

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Hypoxia stabilizes the H 2 O 2 -producing oxidase Nox4 in cardiomyocytes via suppressing autophagy-related lysosomal degradation

Genes to cells : devoted to molecular & cellular mechanisms, 2024-01, Vol.29 (1), p.63-72

2024

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NADPH Oxidases Are Required for Full Platelet Activation In Vitro and Thrombosis In Vivo but Dispensable for Plasma Coagulation and Hemostasis

Arteriosclerosis, thrombosis, and vascular biology, 2021-02, Vol.41 (2), p.683-697

2021

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Endothelial NADPH oxidases: which NOX to target in vascular disease?

Nox (NADPH Oxidase) 1, Nox4, and Nox5 Promote Vascular Permeability and Neovascularization in Retinopathy

Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling

Reactive oxygen species augment contractile responses of saphenous artery in 10-15-day-old but not adult rats: Substantial role of NADPH oxidases

NADPH oxidases in traumatic brain injury – Promising therapeutic targets?

Differential contribution of Nox1, Nox2 and Nox4 to kidney vascular oxidative stress and endothelial dysfunction in obesity

ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice

Coordination between NADPH oxidase and vascular peroxidase 1 promotes dysfunctions of endothelial progenitor cells in hypoxia-induced pulmonary hypertensive rats

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

Magnesium isoglycyrrhizinate alleviates fructose-induced liver oxidative stress and inflammatory injury through suppressing NOXs

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis

NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

Therapeutic potential of NADPH oxidase 1/4 inhibitors

Regulation of Nox and Duox enzymatic activity and expression

Hypoxia-Dependent Regulation of Nonphagocytic NADPH Oxidase Subunit NOX4 in the Pulmonary Vasculature

New insights in the molecular regulation of the NADPH oxidase 2 activity: Negative modulation by Poldip2

Role of NADPH oxidase isoforms NOX1, NOX2 and NOX4 in myocardial ischemia/reperfusion injury

Hypoxia stabilizes the H 2 O 2 -producing oxidase Nox4 in cardiomyocytes via suppressing autophagy-related lysosomal degradation

NADPH Oxidases Are Required for Full Platelet Activation In Vitro and Thrombosis In Vivo but Dispensable for Plasma Coagulation and Hemostasis

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