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Quantitative Structure–Activity Relationship (QSAR) Study Predicts Small-Molecule Binding to RNA Structure

Journal of medicinal chemistry, 2022-05, Vol.65 (10), p.7262-7277

2022

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Discovery of Potent and Broad-Spectrum Pyrazolopyridine-Containing Antivirals against Enteroviruses D68, A71, and Coxsackievirus B3 by Targeting the Viral 2C Protein

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8755-8774

2021

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GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins

Journal of medicinal chemistry, 2020-09, Vol.63 (17), p.9045-9069

2020

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Polypharmacology: challenges and opportunities in drug discovery

Journal of medicinal chemistry, 2014-10, Vol.57 (19), p.7874-7887

2014

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Antiretroviral Activity of Thiosemicarbazone Metal Complexes

Journal of medicinal chemistry, 2010-12, Vol.53 (24), p.8765-8769

2010

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Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12799-12813

2020

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Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2‑Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

Journal of medicinal chemistry, 2015-01, Vol.58 (2), p.651-664

2015

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The ProTide Prodrug Technology: From the Concept to the Clinic

Journal of medicinal chemistry, 2018-03, Vol.61 (6), p.2211-2226

2018

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Novel C,N-Cyclometalated Benzimidazole Ruthenium(II) and Iridium(III) Complexes as Antitumor and Antiangiogenic Agents: A Structure–Activity Relationship Study

Journal of medicinal chemistry, 2015-09, Vol.58 (18), p.7310-7327

2015

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An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

Journal of medicinal chemistry, 2016-07, Vol.59 (14), p.6595-6628

2016

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Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2269-2300

2016

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Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity

Journal of medicinal chemistry, 2015-12, Vol.58 (24), p.9601-9614

2015

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Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

Journal of medicinal chemistry, 2019-01, Vol.62 (2), p.699-726

2019

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Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy

Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14142-14152

2021

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Unraveling the Role of Linker Design in Proteolysis Targeting Chimeras

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8042-8052

2021

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Discovery of Novel Substituted N‑(4-Amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide Analogues as Potent Human Adenovirus Inhibitors

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12830-12852

2020

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Double-Winged 3‑Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV‑1 RNase H with Significant Antiviral Activity

Journal of medicinal chemistry, 2017-06, Vol.60 (12), p.5045-5056

2017

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Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.3306-3331

2022

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Hydrocarbon-stapled peptides: principles, practice, and progress

Journal of medicinal chemistry, 2014-08, Vol.57 (15), p.6275-6288

2014

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Discovery of Highly Selective Inhibitors of the Human Constitutive Proteasome β5c Chymotryptic Subunit

Journal of medicinal chemistry, 2023-01, Vol.66 (2), p.1172-1185

2023

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Recent Progress in the Development of HIV‑1 Protease Inhibitors for the Treatment of HIV/AIDS

Journal of medicinal chemistry, 2016-06, Vol.59 (11), p.5172-5208

2016

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Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV‑2 Infection in Mouse Models

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.2785-2793

2022

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Discovery of Quinoline Analogues as Potent Antivirals against Enterovirus D68 (EV-D68)

Journal of medicinal chemistry, 2019-04, Vol.62 (8), p.4074-4090

2019

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Quantitative Structure–Activity Relationship (QSAR) Study Predicts Small-Molecule Binding to RNA Structure

Discovery of Potent and Broad-Spectrum Pyrazolopyridine-Containing Antivirals against Enteroviruses D68, A71, and Coxsackievirus B3 by Targeting the Viral 2C Protein

GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins

Polypharmacology: challenges and opportunities in drug discovery

Antiretroviral Activity of Thiosemicarbazone Metal Complexes

Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain

Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2‑Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

The ProTide Prodrug Technology: From the Concept to the Clinic

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

Novel C,N-Cyclometalated Benzimidazole Ruthenium(II) and Iridium(III) Complexes as Antitumor and Antiangiogenic Agents: A Structure–Activity Relationship Study

An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

Design and Synthesis of Novel 3-Nitro-1 H -1,2,4-triazole-1,2,3-triazole-1,4-disubstituted Analogs as Promising Antitrypanosomatid Agents: Evaluation of In Vitro Activity against Chagas Disease and Leishmaniasis

Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy

Unraveling the Role of Linker Design in Proteolysis Targeting Chimeras

Discovery of Novel Substituted N‑(4-Amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide Analogues as Potent Human Adenovirus Inhibitors

Double-Winged 3‑Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV‑1 RNase H with Significant Antiviral Activity

Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models

Hydrocarbon-stapled peptides: principles, practice, and progress

Discovery of Highly Selective Inhibitors of the Human Constitutive Proteasome β5c Chymotryptic Subunit

Recent Progress in the Development of HIV‑1 Protease Inhibitors for the Treatment of HIV/AIDS

Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV‑2 Infection in Mouse Models

Discovery of Quinoline Analogues as Potent Antivirals against Enterovirus D68 (EV-D68)

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