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Structural basis of long-range to short-range synaptic transition in NHEJ

Nature (London), 2021-05, Vol.593 (7858), p.294-298

2021

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The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis

Nature communications, 2019-08, Vol.10 (1), p.3588-12, Article 3588

2019

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Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis

Nature communications, 2018-07, Vol.9 (1), p.2642-12, Article 2642

2018

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Horizontal acquisition of a DNA ligase improves DNA damage tolerance in eukaryotes

Nature communications, 2023-11, Vol.14 (1), p.7638-7638, Article 7638

2023

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X‐ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double‐strand break repair impacting cell and cancer biology

Protein science, 2021-09, Vol.30 (9), p.1735-1756

2021

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Pol μ ribonucleotide insertion opposite 8-oxodG facilitates the ligation of premutagenic DNA repair intermediate

Scientific reports, 2020-01, Vol.10 (1), p.940, Article 940

Çağlayan, Melike

2020

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Identification and characterization of novel ligase I inhibitors

Molecular carcinogenesis, 2017-02, Vol.56 (2), p.550-566

2017

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Deletion of DNA ligase IV homolog confers higher gene targeting efficiency on homologous recombination in Komagataella phaffii

FEMS yeast research, 2018-11, Vol.18 (7), p.1

2018

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DNA ligase IV mutations confer shorter lifespan and increased sensitivity to nutrient stress in Drosophila melanogaster

Journal of applied genetics, 2022-02, Vol.63 (1), p.141-144

2022

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Imprecision and DNA Break Repair Biased towards Incompatible End Joining in Leukemia

Molecular cancer research, 2018-03, Vol.16 (3), p.428-438

2018

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An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development

eLife, 2021-09, Vol.10

2021

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Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface

Scientific reports, 2016-03, Vol.6 (1), p.22878-22878, Article 22878

2016

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Deletion Analysis of GH7 Endoglucanase Gene (cel7B) Promoter Region in a Talaromyces cellulolyticus ligD-Disrupted Strain

Applied biochemistry and biotechnology, 2017-12, Vol.183 (4), p.1516-1525

2017

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Structural role for DNA Ligase IV in promoting the fidelity of non-homologous end joining

Nature communications, 2024-02, Vol.15 (1), p.1250-1250

2024

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Dual loss of human POLQ and LIG4 abolishes random integration

Nature communications, 2017-07, Vol.8 (1), p.16112-16112, Article 16112

2017

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Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing

Nature communications, 2022-12, Vol.13 (1), p.7833-7833, Article 7833

2022

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A role for the ATP-dependent DNA ligase lig E of Neisseria gonorrhoeae in biofilm formation

BMC microbiology, 2024-01, Vol.24 (1), p.29-29, Article 29

2024

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miR-22 suppresses DNA ligase III addiction in multiple myeloma

Leukemia, 2019-02, Vol.33 (2), p.487-498

2019

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The DNA binding domain and the C-terminal region of DNA Ligase IV specify its role in V(D)J recombination

PloS one, 2023-02, Vol.18 (2), p.e0282236-e0282236

2023

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Two-tiered enforcement of high-fidelity DNA ligation

Nature communications, 2019-11, Vol.10 (1), p.5431-13, Article 5431

2019

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Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface

Acta crystallographica. Section D, Biological crystallography., 2014-11, Vol.70 (11), p.3043-3056

2014

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Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies

The Journal of clinical investigation, 2018-12, Vol.128 (12), p.5489-5504

2018

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The oncogenic RNA-binding protein SRSF1 regulates LIG1 in non-small cell lung cancer

Laboratory investigation, 2018-12, Vol.98 (12), p.1562-1574

2018

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Radio‐adaptive response, individual radio‐sensitivity and correlation of base excision repair gene polymorphism (hOGG1, APE1, XRCC1, and LIGASE1) in human peripheral blood mononuclear cells exposed to gamma radiation

Environmental and molecular mutagenesis, 2020-06, Vol.61 (5), p.551-559

2020

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Traditional Chinese Medicine Curcumin Sensitizes Human Colon Cancer to Radiation by Altering the Expression of DNA Repair-related Genes

Anticancer research, 2018-01, Vol.38 (1), p.131

2018

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Structural basis of long-range to short-range synaptic transition in NHEJ

The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis

Horizontal acquisition of a DNA ligase improves DNA damage tolerance in eukaryotes

X‐ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double‐strand break repair impacting cell and cancer biology

Pol μ ribonucleotide insertion opposite 8-oxodG facilitates the ligation of premutagenic DNA repair intermediate

Identification and characterization of novel ligase I inhibitors

Deletion of DNA ligase IV homolog confers higher gene targeting efficiency on homologous recombination in Komagataella phaffii

DNA ligase IV mutations confer shorter lifespan and increased sensitivity to nutrient stress in Drosophila melanogaster

Imprecision and DNA Break Repair Biased towards Incompatible End Joining in Leukemia

An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development

Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface

Deletion Analysis of GH7 Endoglucanase Gene (cel7B) Promoter Region in a Talaromyces cellulolyticus ligD-Disrupted Strain

Structural role for DNA Ligase IV in promoting the fidelity of non-homologous end joining

Dual loss of human POLQ and LIG4 abolishes random integration

Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing

A role for the ATP-dependent DNA ligase lig E of Neisseria gonorrhoeae in biofilm formation

miR-22 suppresses DNA ligase III addiction in multiple myeloma

The DNA binding domain and the C-terminal region of DNA Ligase IV specify its role in V(D)J recombination

Two-tiered enforcement of high-fidelity DNA ligation

Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface

Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies

The oncogenic RNA-binding protein SRSF1 regulates LIG1 in non-small cell lung cancer

Radio‐adaptive response, individual radio‐sensitivity and correlation of base excision repair gene polymorphism (hOGG1, APE1, XRCC1, and LIGASE1) in human peripheral blood mononuclear cells exposed to gamma radiation

Traditional Chinese Medicine Curcumin Sensitizes Human Colon Cancer to Radiation by Altering the Expression of DNA Repair-related Genes

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