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PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

Proceedings of the National Academy of Sciences - PNAS, 2016-06, Vol.113 (26), p.7124-7129

2016

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Recent advances in the evolutionary engineering of industrial biocatalysts

Genomics (San Diego, Calif.), 2014-12, Vol.104 (6), p.406-411

2014

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Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor

Clinical cancer research, 2007-03, Vol.13 (5), p.1576-1583

2007

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Refactoring the Genetic Code for Increased Evolvability

mBio, 2017-11, Vol.8 (6)

2017

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Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

Chemistry & biology, 2015-06, Vol.22 (6), p.755-763

2015

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The LASER database: Formalizing design rules for metabolic engineering

Metabolic engineering communications, 2015-12, Vol.2 (C), p.30-38

2015

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Evolved osmotolerant Escherichia coli mutants frequently exhibit defective N-acetylglucosamine catabolism and point mutations in cell shape-regulating protein MreB

Applied and Environmental Microbiology, 2014-06, Vol.80 (12), p.3729-3740

2014

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

Oncogene, 1999-07, Vol.18 (28), p.4047-4054

1999

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Quantifying complexity in metabolic engineering using the LASER database

Metabolic engineering communications, 2016-12, Vol.3 (C), p.227-233

2016

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Clinical experience of MEK inhibitors in cancer therapy

Biochimica et biophysica acta, 2007-08, Vol.1773 (8), p.1248-1255

2007

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Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors

Molecular cancer therapeutics, 2022-03, Vol.21 (3), p.397-406

2022

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An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage

Cancer research (Chicago, Ill.), 2000-02, Vol.60 (3), p.566-572

2000

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Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity

The Journal of biological chemistry, 2000-04, Vol.275 (14), p.10342-10348

2000

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Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 Inhibit Apoptosis and Maintain Cell Functionality

The Journal of biological chemistry, 2000-05, Vol.275 (21), p.16007-16014

2000

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Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models

The Journal of pharmacology and experimental therapeutics, 1998-02, Vol.284 (2), p.687

1998

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Cytosolic 85-kDa Phospholipase A2-mediated Release of Arachidonic Acid Is Critical for Proliferation of Vascular Smooth Muscle Cells

The Journal of biological chemistry, 1997-11, Vol.272 (48), p.30504-30511

1997

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Phase 1 study of OKI-179, an oral class 1-selective depsipeptide HDAC inhibitor, in patients with advanced solid tumors: Final results

Journal of clinical oncology, 2021-05, Vol.39 (15_suppl), p.3075-3075

2021

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Depletion of Human Monocyte 85-kDa Phospholipase A2 Does Not Alter Leukotriene Formation

The Journal of biological chemistry, 1997-01, Vol.272 (2), p.759-765

1997

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ARV-330: Androgen receptor PROTAC degrader for prostate cancer

Journal of clinical oncology, 2016-01, Vol.34 (2_suppl), p.267-267

2016

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Abstract LB-097: Targeted degradation of the androgen receptor in prostate cancer

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.LB-097-LB-097

2015

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Abstract PR08: ARV-330: An androgen receptor PROTAC degrader for prostate cancer

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.PR08-PR08

2015

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Abstract 2514: ARRY-162, A Potent and Selective MEK 1/2 Inhibitor, Shows Enhanced Efficacy in Combination with Other Targeted Kinase Inhibitors and with Chemotherapy

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.2514-2514

2010

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Inhibitors of coenzyme A-independent transacylase induce apoptosis in human HL-60 cells

The Journal of pharmacology and experimental therapeutics, 1996-11, Vol.279 (2), p.956

1996

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Influence of isoproterenol and phosphodiesterase inhibitors on platelet-activating factor biosynthesis in the human neutrophil

The Journal of immunology (1950), 1993-07, Vol.151 (1), p.339

1993

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Beta-lactams SB 212047 and SB 216754 are irreversible, time-dependent inhibitors of coenzyme A-independent transacylase

Molecular pharmacology, 1998-02, Vol.53 (2), p.322-329

1998

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PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

Recent advances in the evolutionary engineering of industrial biocatalysts

Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor

Refactoring the Genetic Code for Increased Evolvability

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

The LASER database: Formalizing design rules for metabolic engineering

Evolved osmotolerant Escherichia coli mutants frequently exhibit defective N-acetylglucosamine catabolism and point mutations in cell shape-regulating protein MreB

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

Quantifying complexity in metabolic engineering using the LASER database

Clinical experience of MEK inhibitors in cancer therapy

Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors

An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage

Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity

Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 Inhibit Apoptosis and Maintain Cell Functionality

Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models

Cytosolic 85-kDa Phospholipase A2-mediated Release of Arachidonic Acid Is Critical for Proliferation of Vascular Smooth Muscle Cells

Phase 1 study of OKI-179, an oral class 1-selective depsipeptide HDAC inhibitor, in patients with advanced solid tumors: Final results

Depletion of Human Monocyte 85-kDa Phospholipase A2 Does Not Alter Leukotriene Formation

ARV-330: Androgen receptor PROTAC degrader for prostate cancer

Abstract LB-097: Targeted degradation of the androgen receptor in prostate cancer

Abstract PR08: ARV-330: An androgen receptor PROTAC degrader for prostate cancer

Abstract 2514: ARRY-162, A Potent and Selective MEK 1/2 Inhibitor, Shows Enhanced Efficacy in Combination with Other Targeted Kinase Inhibitors and with Chemotherapy

Inhibitors of coenzyme A-independent transacylase induce apoptosis in human HL-60 cells

Influence of isoproterenol and phosphodiesterase inhibitors on platelet-activating factor biosynthesis in the human neutrophil

Beta-lactams SB 212047 and SB 216754 are irreversible, time-dependent inhibitors of coenzyme A-independent transacylase

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