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Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus

Trends in endocrinology and metabolism, 2016-01, Vol.27 (1), p.24-34

Tang, Wei-Jen

2016

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Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

Nature (London), 2014-07, Vol.511 (7507), p.94-98

2014

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

Nature, 2006-10, Vol.443 (7113), p.870-874

2006

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In vivo epidermal migration requires focal adhesion targeting of ACF7

Nature communications, 2016-05, Vol.7 (1), p.11692-15, Article 11692

2016

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Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme

The EMBO journal, 2010-12, Vol.29 (23), p.3952-3966

2010

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Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition

Nature communications, 2022-04, Vol.13 (1), p.1833-1833, Article 1833

2022

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The adenylyl cyclase activity of anthrax edema factor

Molecular aspects of medicine, 2009-12, Vol.30 (6), p.423-430

2009

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Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3

Proceedings of the National Academy of Sciences - PNAS, 2016-05, Vol.113 (18), p.5000-5005

2016

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Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA and edema factor

PloS one, 2013-07, Vol.8 (7), p.e70223-e70223

2013

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Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

Proceedings of the National Academy of Sciences - PNAS, 2013-08, Vol.110 (34), p.13827-13832

2013

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ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics

Nature communications, 2017-05, Vol.8 (1), p.15375-16, Article 15375

2017

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Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin

PloS one, 2010-05, Vol.5 (5), p.e10504

2010

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Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease

Structure (London), 2014-07, Vol.22 (7), p.996-1007

2014

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Structure–activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme

European journal of medicinal chemistry, 2015-01, Vol.90 (C), p.547-567

2015

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Catalytic Mechanism of Amyloid‑β Peptide Degradation by Insulin Degrading Enzyme: Insights from Quantum Mechanics and Molecular Mechanics Style Møller–Plesset Second Order Perturbation Theory Calculation

Journal of chemical information and modeling, 2018-09, Vol.58 (9), p.1926-1934

2018

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Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin

The EMBO journal, 2005-09, Vol.24 (18), p.3190-3201

2005

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Degradation of Alzheimer’s Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme

Journal of molecular biology, 2021-06, Vol.433 (13), p.166993-166993, Article 166993

2021

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Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

The Journal of biological chemistry, 2009-05, Vol.284 (21), p.14177-14188

2009

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Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor

Nature biotechnology, 2004-06, Vol.22 (6), p.717-723

2004

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Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor

The EMBO journal, 2005-03, Vol.24 (5), p.929-941

2005

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Cellular Functions and X-ray Structure of Anthrolysin O, a Cholesterol-dependent Cytolysin Secreted by Bacillus anthracis

The Journal of biological chemistry, 2009-05, Vol.284 (21), p.14645-14656

2009

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Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor

Proceedings of the National Academy of Sciences - PNAS, 2010-06, Vol.107 (25), p.11277-11282

2010

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Structure of Substrate-free Human Insulin-degrading Enzyme (IDE) and Biophysical Analysis of ATP-induced Conformational Switch of IDE

The Journal of biological chemistry, 2007-08, Vol.282 (35), p.25453-25463

2007

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Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

In vivo epidermal migration requires focal adhesion targeting of ACF7

Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme

Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition

The adenylyl cyclase activity of anthrax edema factor

Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3

Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA and edema factor

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics

Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin

Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease

Structure–activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme

Catalytic Mechanism of Amyloid‑β Peptide Degradation by Insulin Degrading Enzyme: Insights from Quantum Mechanics and Molecular Mechanics Style Møller–Plesset Second Order Perturbation Theory Calculation

Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin

Degradation of Alzheimer’s Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor

Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor

Cellular Functions and X-ray Structure of Anthrolysin O, a Cholesterol-dependent Cytolysin Secreted by Bacillus anthracis

Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor

Structure of Substrate-free Human Insulin-degrading Enzyme (IDE) and Biophysical Analysis of ATP-induced Conformational Switch of IDE

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