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Update on Research and Development Pipeline: Tuberculosis Vaccines

Clinical infectious diseases, 2010-05, Vol.50 (Supplement-3), p.S178-S183

2010

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A New Recombinant Bacille Calmette-Guérin Vaccine Safely Induces Significantly Enhanced Tuberculosis-Specific Immunity in Human Volunteers

The Journal of infectious diseases, 2008-11, Vol.198 (10), p.1491-1501

2008

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Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses

BMC medical genomics, 2008-05, Vol.1 (1), p.18-18

2008

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Protective Immune Responses to a Recombinant Adenovirus Type 35 Tuberculosis Vaccine in Two Mouse Strains: CD4 and CD8 T-Cell Epitope Mapping and Role of Gamma Interferon

Infection and Immunity, 2007-08, Vol.75 (8), p.4105-4115

2007

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Correlates, Surrogates, and Vaccines

The Journal of infectious diseases, 2007-11, Vol.196 (9), p.1279-1281

2007

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Genetic immunization in the lung induces potent local and systemic immune responses

Proceedings of the National Academy of Sciences - PNAS, 2010-12, Vol.107 (51), p.22213-22218

2010

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Non-clinical efficacy and safety of HyVac4:IC31 vaccine administered in a BCG prime–boost regimen

Vaccine, 2010-01, Vol.28 (4), p.1084-1093

2010

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Recombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8+ T-Cell Responses in Rhesus Macaques

Journal of Virology, 2010-04, Vol.84 (7), p.3699-3706

2010

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Safety and Immunogenicity of Novel Recombinant BCG and Modified Vaccinia Virus Ankara Vaccines in Neonate Rhesus Macaques

Journal of Virology, 2010-08, Vol.84 (15), p.7815-7821

2010

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Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

Nature (London), 2012-02, Vol.482 (7383), p.89-93

2012

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Advances in tuberculosis vaccine strategies

Nature reviews. Microbiology, 2006-06, Vol.4 (6), p.469-476

2006

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Novel Recombinant Mycobacterium bovis BCG, Ovine Atadenovirus, and Modified Vaccinia Virus Ankara Vaccines Combine To Induce Robust Human Immunodeficiency Virus-Specific CD4 and CD8 T-Cell Responses in Rhesus Macaques

Journal of Virology, 2010-06, Vol.84 (12), p.5898-5908

2010

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Induction and Regulation of T-Cell Immunity by the Novel Tuberculosis Vaccine M72/AS01 in South African Adults

American journal of respiratory and critical care medicine, 2013-08, Vol.188 (4), p.492-502

2013

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Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge

The Journal of immunology (1950), 2014-08, Vol.193 (4), p.1799-1811

2014

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The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4+ and CD8+ T Cells in Adults

American journal of respiratory and critical care medicine, 2010-06, Vol.181 (12), p.1407-1417

2010

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Safety and Immunogenicity of Adenovirus 35 Tuberculosis Vaccine Candidate in Adults with Active or Previous Tuberculosis. A Randomized Trial

American journal of respiratory and critical care medicine, 2017-05, Vol.195 (9), p.1171-1180

2017

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Tuberculosis vaccine research: the impact of immunology

Current opinion in immunology, 2009-06, Vol.21 (3), p.331-338

2009

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The novel tuberculosis vaccine, AERAS-402, is safe in healthy infants previously vaccinated with BCG, and induces dose-dependent CD4 and CD8T cell responses

Vaccine, 2014-10, Vol.32 (45), p.5908-5917

2014

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Protective Efficacy of a Second Pneumococcal Conjugate Vaccine against Pneumococcal Acute Otitis Media in Infants and Children: Randomized, Controlled Trial of a 7-Valent Pneumococcal Polysaccharide-Meningococcal Outer Membrane Protein Complex Conjugate Vaccine in 1666 Children

Clinical infectious diseases, 2003-11, Vol.37 (9), p.1155-1164

2003

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Optimizing HIV‐1‐specific CD8+ T‐cell induction by recombinant BCG in prime‐boost regimens with heterologous viral vectors

European journal of immunology, 2011-12, Vol.41 (12), p.3542-3552

2011

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Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

The New England journal of medicine, 1996-06, Vol.334 (26), p.1697-1702

1996

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A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 vaccine: Evidence for transient t cell responses in peripheral blood and robust sustained responses in the lungs

Human vaccines & immunotherapeutics, 2014-08, Vol.10 (8), p.2199-2210

2014

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Attenuated Shigella as a DNA Delivery Vehicle for DNA-Mediated Immunization

Science (American Association for the Advancement of Science), 1995-10, Vol.270 (5234), p.299-302

1995

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Phase I/IIa Safety, Immunogenicity, and Efficacy Trial of NYVAC-Pf7, a Pox-Vectored, Multiantigen, Multistage Vaccine Candidate for Plasmodium falciparum Malaria

The Journal of infectious diseases, 1998-06, Vol.177 (6), p.1664-1673

1998

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Update on Research and Development Pipeline: Tuberculosis Vaccines

A New Recombinant Bacille Calmette-Guérin Vaccine Safely Induces Significantly Enhanced Tuberculosis-Specific Immunity in Human Volunteers

Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses

Protective Immune Responses to a Recombinant Adenovirus Type 35 Tuberculosis Vaccine in Two Mouse Strains: CD4 and CD8 T-Cell Epitope Mapping and Role of Gamma Interferon

Correlates, Surrogates, and Vaccines

Genetic immunization in the lung induces potent local and systemic immune responses

Non-clinical efficacy and safety of HyVac4:IC31 vaccine administered in a BCG prime–boost regimen

Recombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8+ T-Cell Responses in Rhesus Macaques

Safety and Immunogenicity of Novel Recombinant BCG and Modified Vaccinia Virus Ankara Vaccines in Neonate Rhesus Macaques

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

Advances in tuberculosis vaccine strategies

Novel Recombinant Mycobacterium bovis BCG, Ovine Atadenovirus, and Modified Vaccinia Virus Ankara Vaccines Combine To Induce Robust Human Immunodeficiency Virus-Specific CD4 and CD8 T-Cell Responses in Rhesus Macaques

Induction and Regulation of T-Cell Immunity by the Novel Tuberculosis Vaccine M72/AS01 in South African Adults

Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge

The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4+ and CD8+ T Cells in Adults

Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis

Safety and Immunogenicity of Adenovirus 35 Tuberculosis Vaccine Candidate in Adults with Active or Previous Tuberculosis. A Randomized Trial

Tuberculosis vaccine research: the impact of immunology

The novel tuberculosis vaccine, AERAS-402, is safe in healthy infants previously vaccinated with BCG, and induces dose-dependent CD4 and CD8T cell responses

Protective Efficacy of a Second Pneumococcal Conjugate Vaccine against Pneumococcal Acute Otitis Media in Infants and Children: Randomized, Controlled Trial of a 7-Valent Pneumococcal Polysaccharide-Meningococcal Outer Membrane Protein Complex Conjugate Vaccine in 1666 Children

Optimizing HIV‐1‐specific CD8+ T‐cell induction by recombinant BCG in prime‐boost regimens with heterologous viral vectors

Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 vaccine: Evidence for transient t cell responses in peripheral blood and robust sustained responses in the lungs

Attenuated Shigella as a DNA Delivery Vehicle for DNA-Mediated Immunization

Phase I/IIa Safety, Immunogenicity, and Efficacy Trial of NYVAC-Pf7, a Pox-Vectored, Multiantigen, Multistage Vaccine Candidate for Plasmodium falciparum Malaria

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