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Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications

Cells (Basel, Switzerland), 2019-04, Vol.8 (5), p.403

2019

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Cardiotoxicity and Heart Failure: Lessons from Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Anticancer Drugs

Cells (Basel, Switzerland), 2020-04, Vol.9 (4), p.1001

Sachinidis, Agapios

2020

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High-throughput base editing: a promising technology for precision medicine and drug discovery

Signal transduction and targeted therapy, 2021-06, Vol.6 (1), p.221-221, Article 221

Sachinidis, Agapios

2021

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MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes

Archives of toxicology, 2016-12, Vol.90 (12), p.3087-3098

2016

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Enhanced hippocampal type II theta activity AND altered theta architecture in mice lacking the Cav3.2 T-type voltage-gated calcium channel

Scientific reports, 2021-01, Vol.11 (1), p.1099-1099, Article 1099

2021

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Stem Cell‐Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants

Stem cells translational medicine, 2016-04, Vol.5 (4), p.476-487

2016

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Sex- and region-specific cortical and hippocampal whole genome transcriptome profiles from control and APP/PS1 Alzheimer's disease mice

PloS one, 2024-02, Vol.19 (2), p.e0296959-e0296959

2024

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Chemoprotective mechanism of the natural compounds, epigallocatechin-3-O-gallate, quercetin and curcumin against cancer and cardiovascular diseases

Current medicinal chemistry, 2009-04, Vol.16 (12), p.1451

2009

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Human Embryonic and Induced Pluripotent Stem Cell Based Toxicity Testing Models: Future Applications in New Drug Discovery

Current medicinal chemistry, 2016-09, Vol.23 (30), p.3495

2016

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Evaluation of Developmental Toxicants and Signaling Pathways in a Functional Test Based on the Migration of Human Neural Crest Cells

Environmental health perspectives, 2012-08, Vol.120 (8), p.1116-1122

2012

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Cardiomyocytes facing fibrotic conditions re-express extracellular matrix transcripts

Acta biomaterialia, 2019-04, Vol.89, p.180-192

2019

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Maximum Diastolic Potential of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Depends Critically on IKr

PloS one, 2012-07, Vol.7 (7), p.e40288

2012

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Signaling molecules, transcription growth factors and other regulators revealed from in-vivo and in-vitro models for the regulation of cardiac development

International journal of cardiology, 2015-03, Vol.183, p.117-128

2015

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Live Cell Imaging funktionaler Parameter von Kardiomyozyten

Biospektrum, 2023-06, Vol.29 (4), p.358-361

2023

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Epigenetic Mechanisms Involved in the Cardiovascular Toxicity of Anticancer Drugs

Frontiers in cardiovascular medicine, 2021-04, Vol.8, p.658900-658900

2021

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Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells

Nature communications, 2014-04, Vol.5 (1), p.3719-3719, Article 3719

2014

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High-efficient serum-free differentiation of endothelial cells from human iPS cells

Stem cell research & therapy, 2022-06, Vol.13 (1), p.251-251, Article 251

2022

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Identification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells

PloS one, 2012-08, Vol.7 (8), p.e44228

2012

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Transcriptional changes associated with advancing stages of heart failure underlie atrial and ventricular arrhythmogenesis

PloS one, 2019-05, Vol.14 (5), p.e0216928-e0216928

2019

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Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5

PloS one, 2018-03, Vol.13 (3), p.e0194428-e0194428

2018

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A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

Archives of toxicology, 2015-09, Vol.89 (9), p.1599-1618

2015

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Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now

Cells (Basel, Switzerland), 2021-11, Vol.10 (11), p.3112

2021

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Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications

Cardiotoxicity and Heart Failure: Lessons from Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Anticancer Drugs

High-throughput base editing: a promising technology for precision medicine and drug discovery

MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes

Enhanced hippocampal type II theta activity AND altered theta architecture in mice lacking the Cav3.2 T-type voltage-gated calcium channel

Stem Cell‐Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants

Sex- and region-specific cortical and hippocampal whole genome transcriptome profiles from control and APP/PS1 Alzheimer's disease mice

Chemoprotective mechanism of the natural compounds, epigallocatechin-3-O-gallate, quercetin and curcumin against cancer and cardiovascular diseases

Human Embryonic and Induced Pluripotent Stem Cell Based Toxicity Testing Models: Future Applications in New Drug Discovery

Evaluation of Developmental Toxicants and Signaling Pathways in a Functional Test Based on the Migration of Human Neural Crest Cells

Cardiomyocytes facing fibrotic conditions re-express extracellular matrix transcripts

Maximum Diastolic Potential of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Depends Critically on IKr

Signaling molecules, transcription growth factors and other regulators revealed from in-vivo and in-vitro models for the regulation of cardiac development

Live Cell Imaging funktionaler Parameter von Kardiomyozyten

Epigenetic Mechanisms Involved in the Cardiovascular Toxicity of Anticancer Drugs

Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells

Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease

High-efficient serum-free differentiation of endothelial cells from human iPS cells

Identification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells

Transcriptional changes associated with advancing stages of heart failure underlie atrial and ventricular arrhythmogenesis

Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5

Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now

A Genome-Scale RNAi Screen for Oct4 Modulators Defines a Role of the Paf1 Complex for Embryonic Stem Cell Identity

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