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Towards HBV curative therapies

Liver international, 2018-02, Vol.38 (S1), p.102-114

2018

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Toward Elimination of Hepatitis B Virus Using Novel Drugs, Approaches, and Combined Modalities

Clinics in liver disease, 2016-11, Vol.20 (4), p.737

2016

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Comprehensive high-throughput meta-analysis of differentially expressed microRNAs in transcriptomic datasets reveals significant disruption of MAPK/JNK signal transduction pathway in Adult T-cell leukemia/lymphoma

Infectious agents and cancer, 2021-06, Vol.16 (1), p.1-49, Article 49

2021

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Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanisms

The Journal of biological chemistry, 2008-08, Vol.283 (32), p.22222-22232

2008

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Approaches to hepatitis C treatment and cure using NS5A inhibitors

Infection and drug resistance, 2014-01, Vol.7 (default), p.41-56

2014

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Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action

Journal of Virology, 2006-12, Vol.80 (24), p.12283-12292

2006

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Mutations M184V and Y115F in HIV-1 Reverse Transcriptase Discriminate against “Nucleotide-competing Reverse Transcriptase Inhibitors”

The Journal of biological chemistry, 2008-10, Vol.283 (44), p.29904-29911

2008

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HIV-1 Reverse Transcriptase Connection Domain Mutations: Dynamics of Emergence and Implications for Success of Combination Antiretroviral Therapy

Clinical infectious diseases, 2010-09, Vol.51 (5), p.620-628

2010

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The best backbone for HIV prevention, treatment, and elimination: Emtricitabine+tenofovir

Antiviral Therapy, 2022-04, Vol.27 (2), p.13596535211067599-13596535211067599

2022

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Impact of Primer-induced Conformational Dynamics of HIV-1 Reverse Transcriptase on Polymerase Translocation and Inhibition

The Journal of biological chemistry, 2011-08, Vol.286 (34), p.29575-29583

2011

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HIV nucleoside reverse transcriptase inhibitors

European journal of medicinal chemistry, 2022-10, Vol.240, p.114554-114554, Article 114554

2022

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Characterization of β-d- N 4 -Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus

Antimicrobial agents and chemotherapy, 2017-04, Vol.61 (4)

2017

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Lessons Learned from In-Person Conferences in the Times of COVID-19

International journal of environmental research and public health, 2022-12, Vol.20 (1), p.510

2022

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2′-Chloro,2′-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5424-5437

2017

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Discovery of a Series of 2′-α-Fluoro,2′-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus

Journal of medicinal chemistry, 2019-02, Vol.62 (4), p.1859-1874

2019

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β‑d‑2′‑C‑Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5′-Triphosphate Forms

Journal of medicinal chemistry, 2015-04, Vol.58 (8), p.3445-3458

2015

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Chutes and ladders in hepatitis C nucleoside drug development

Antiviral research, 2014-02, Vol.102, p.119-147

2014

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Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase

Antimicrobial agents and chemotherapy, 2017-08, Vol.61 (8)

2017

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Binding Kinetics and Affinities of Heterodimeric versus Homodimeric HIV‑1 Reverse Transcriptase on DNA–DNA Substrates at the Single-Molecule Level

The journal of physical chemistry. B, 2013-04, Vol.117 (16), p.4560-4567

2013

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Discovery, characterization, and lead optimization of 7-azaindole non-nucleoside HIV-1 reverse transcriptase inhibitors

Bioorganic & medicinal chemistry letters, 2016-08, Vol.26 (16), p.4101-4105

2016

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Formation of a Quaternary Complex of HIV-1 Reverse Transcriptase with a Nucleotide-competing Inhibitor and Its ATP Enhancer

The Journal of biological chemistry, 2013-06, Vol.288 (24), p.17336-17346

2013

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Intracellular metabolism and potential cardiotoxicity of a β-D-2'-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication

Nucleosides, nucleotides & nucleic acids, 2020-02, Vol.39 (1-3), p.204-224

2020

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Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094

Antimicrobial agents and chemotherapy, 2016-08, Vol.60 (8), p.4659-4669

2016

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Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus

Antimicrobial agents and chemotherapy, 2017-04, Vol.61 (4)

2017

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Effects of mutations in the connection and RNase H domains of HIV-1 reverse transcriptase on drug susceptibility

AIDS reviews, 2008-10, Vol.10 (4), p.224-235

2008

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Towards HBV curative therapies

Toward Elimination of Hepatitis B Virus Using Novel Drugs, Approaches, and Combined Modalities

Comprehensive high-throughput meta-analysis of differentially expressed microRNAs in transcriptomic datasets reveals significant disruption of MAPK/JNK signal transduction pathway in Adult T-cell leukemia/lymphoma

Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanisms

Approaches to hepatitis C treatment and cure using NS5A inhibitors

Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action

Mutations M184V and Y115F in HIV-1 Reverse Transcriptase Discriminate against “Nucleotide-competing Reverse Transcriptase Inhibitors”

HIV-1 Reverse Transcriptase Connection Domain Mutations: Dynamics of Emergence and Implications for Success of Combination Antiretroviral Therapy

The best backbone for HIV prevention, treatment, and elimination: Emtricitabine+tenofovir

Impact of Primer-induced Conformational Dynamics of HIV-1 Reverse Transcriptase on Polymerase Translocation and Inhibition

HIV nucleoside reverse transcriptase inhibitors

Characterization of β-d- N 4 -Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus

Lessons Learned from In-Person Conferences in the Times of COVID-19

2′-Chloro,2′-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture

Discovery of a Series of 2′-α-Fluoro,2′-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus

β‑d‑2′‑C‑Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5′-Triphosphate Forms

Chutes and ladders in hepatitis C nucleoside drug development

Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase

Binding Kinetics and Affinities of Heterodimeric versus Homodimeric HIV‑1 Reverse Transcriptase on DNA–DNA Substrates at the Single-Molecule Level

Discovery, characterization, and lead optimization of 7-azaindole non-nucleoside HIV-1 reverse transcriptase inhibitors

Formation of a Quaternary Complex of HIV-1 Reverse Transcriptase with a Nucleotide-competing Inhibitor and Its ATP Enhancer

Intracellular metabolism and potential cardiotoxicity of a β-D-2'-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094

Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus

Effects of mutations in the connection and RNase H domains of HIV-1 reverse transcriptase on drug susceptibility

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