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The structural modification of natural products for novel drug discovery

Expert opinion on drug discovery, 2017-02, Vol.12 (2), p.121-140

2017

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Discovery of Novel Tacrine–Pyrimidone Hybrids as Potent Dual AChE/GSK‑3 Inhibitors for the Treatment of Alzheimer’s Disease

Journal of medicinal chemistry, 2021-06, Vol.64 (11), p.7483-7506

2021

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Synthesis, biological evaluation and mechanism studies of C-23 modified 23-hydroxybetulinic acid derivatives as anticancer agents

European journal of medicinal chemistry, 2019-11, Vol.182, p.111659-111659, Article 111659

2019

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Design and synthesis of NAD(P)H: Quinone oxidoreductase (NQO1)-activated prodrugs of 23-hydroxybetulinic acid with enhanced antitumor properties

European journal of medicinal chemistry, 2022-10, Vol.240, p.114575-114575, Article 114575

2022

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Discovery of novel vinyl sulfone derivatives as anti-tumor agents with microtubule polymerization inhibitory and vascular disrupting activities

European journal of medicinal chemistry, 2018-09, Vol.157, p.1068-1080

2018

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Design, synthesis and biological evaluation of novel 9-N-substituted-13-alkylberberine derivatives from Chinese medicine as anti-hepatocellular carcinoma agents

Bioorganic & medicinal chemistry, 2023-02, Vol.79, p.117156, Article 117156

2023

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Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors

European journal of medicinal chemistry, 2020-12, Vol.207, p.112716-112716, Article 112716

2020

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Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo

European journal of medicinal chemistry, 2023-09, Vol.257, p.115529-115529, Article 115529

2023

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Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities

European journal of medicinal chemistry, 2021-04, Vol.216, p.113316-113316, Article 113316

2021

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Design, synthesis and biological evaluation of isochroman-4-one hybrids bearing piperazine moiety as antihypertensive agent candidates

Bioorganic & medicinal chemistry, 2019-07, Vol.27 (13), p.2764-2770

2019

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Synthesis, Biological Evaluation of Fluorescent 23-Hydroxybetulinic Acid Probes, and Their Cellular Localization Studies

ACS medicinal chemistry letters, 2018-10, Vol.9 (10), p.1030-1034

2018

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Design, synthesis, biological evaluation, and docking study of 4‐isochromanone hybrids bearing N‐benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors (part II)

Chemical biology & drug design, 2018-03, Vol.91 (3), p.756-762

2018

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Discovery of Novel 4‑Arylisochromenes as Anticancer Agents Inhibiting Tubulin Polymerization

ACS medicinal chemistry letters, 2018-10, Vol.9 (10), p.974-979

2018

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Development and Validation of a Nomogram for Predicting the Risk of Coronavirus-Associated Acute Respiratory Distress Syndrome: A Retrospective Cohort Study

Infection and drug resistance, 2022-01, Vol.15, p.2371-2381

2022

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The structural modification of natural products for novel drug discovery

Discovery of Novel Tacrine–Pyrimidone Hybrids as Potent Dual AChE/GSK‑3 Inhibitors for the Treatment of Alzheimer’s Disease

Synthesis, biological evaluation and mechanism studies of C-23 modified 23-hydroxybetulinic acid derivatives as anticancer agents

Design and synthesis of NAD(P)H: Quinone oxidoreductase (NQO1)-activated prodrugs of 23-hydroxybetulinic acid with enhanced antitumor properties

Discovery of novel vinyl sulfone derivatives as anti-tumor agents with microtubule polymerization inhibitory and vascular disrupting activities

Design, synthesis and biological evaluation of novel 9-N-substituted-13-alkylberberine derivatives from Chinese medicine as anti-hepatocellular carcinoma agents

Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors

Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo

Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities

Design, synthesis and biological evaluation of isochroman-4-one hybrids bearing piperazine moiety as antihypertensive agent candidates

Synthesis, Biological Evaluation of Fluorescent 23-Hydroxybetulinic Acid Probes, and Their Cellular Localization Studies

Design, synthesis, biological evaluation, and docking study of 4‐isochromanone hybrids bearing N‐benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors (part II)

Discovery of Novel 4‑Arylisochromenes as Anticancer Agents Inhibiting Tubulin Polymerization

Development and Validation of a Nomogram for Predicting the Risk of Coronavirus-Associated Acute Respiratory Distress Syndrome: A Retrospective Cohort Study

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