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Systematic LC/MS metabolite identification in drug discovery

Analytical chemistry (Washington), 2001-08, Vol.73 (15), p.430A-439A

2001

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Chiral liquid chromatography-tandem mass spectrometric methods for stereoisomeric pharmaceutical determinations

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-06, Vol.820 (1), p.1-8

2005

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Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

Psychopharmacologia, 2005-10, Vol.182 (1), p.132-143

2005

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Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice

Cancer research (Chicago, Ill.), 1998-11, Vol.58 (21), p.4947-4956

1998

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Rheumatologie im Spiegel der Medien und Werbung am Beispiel des Rheumazentrum Rhein-Ruhr

Zeitschrift für Rheumatologie, 2018-05, Vol.77 (4), p.300-308

2018

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Rheumatology in the mirror of media and advertising exemplified by the Rheumazentrum Rhein-Ruhr

Zeitschrift für Rheumatologie, 2018-05, Vol.77 (4), p.300-308

2018

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Quantitative screening and matrix effect studies of drug discovery compounds in monkey plasma using fast-gradient liquid chromatography/tandem mass spectrometry

Rapid communications in mass spectrometry, 2001-12, Vol.15 (24), p.2481-2487

2001

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Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery

Rapid communications in mass spectrometry, 2001-01, Vol.15 (5), p.335-340

2001

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Principles and applications of LC-MS in new drug discovery

Drug discovery today, 2005-10, Vol.10 (20), p.1357-1367

Korfmacher, Walter A

2005

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Matrix-assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue

Rapid communications in mass spectrometry, 2006-03, Vol.20 (6), p.965-972

2006

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Direct simultaneous analysis of plasma samples for a drug discovery compound and its hydroxyl metabolite using mixed-function column liquid chromatography-tandem mass spectrometry

Analyst (London), 2001-12, Vol.126 (12), p.2139-2143

2001

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Examining the Principles in Principled Conservatism: The Role of Responsibility Stereotypes as Cues for Deservingness in Racial Policy Decisions

Journal of personality and social psychology, 2006-01, Vol.90 (1), p.109-128

2006

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HPLC-API/MS/MS: a powerful tool for integrating drug metabolism into the drug discovery process

Drug discovery today, 1997-12, Vol.2 (12), p.532-537

1997

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Microsample Determination of Lovastatin and its Hydroxy Acid Metabolite in Mouse and Rat Plasma by Liquid Chromatography/Ionspray Tandem Mass Spectrometry

Journal of mass spectrometry., 1997-04, Vol.32 (4), p.379-387

1997

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Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats

Drug Discovery Today, 1999-05, Vol.4 (5), p.232-237

1999

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Pharmacokinetic screening for the selection of new drug discovery candidates is greatly enhanced through the use of liquid chromatography–atmospheric pressure ionization tandem mass spectrometry

Journal of Chromatography A, 1997-08, Vol.777 (1), p.61-66

1997

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High-performance liquid chromatography—thermospray mass spectrometry of ten sulfonamide antibiotics: Analysis in milk at the ppb level

Journal of Chromatography A, 1993-01, Vol.629 (2), p.267-276

1993

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Direct analysis of plasma samples for drug discovery compounds using mixed-function column liquid chromatography tandem mass spectrometry

Rapid communications in mass spectrometry, 2000-08, Vol.14 (15), p.1384-1390

2000

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Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry

Journal of mass spectrometry., 2003-10, Vol.38 (10), p.1081-1092

2003

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Investigation of matrix effects in bioanalytical high-performance liquid chromatography/tandem mass spectrometric assays: application to drug discovery

Rapid communications in mass spectrometry, 2003-01, Vol.17 (1), p.97-103

2003

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Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice

Cancer chemotherapy and pharmacology, 1999, Vol.43 (1), p.50-58

1999

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Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models

European journal of pharmacology, 2010-03, Vol.630 (1), p.112-120

2010

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The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2519-2523

2009

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Fungal transformations of antihistamines: metabolism of brompheniramine, chlorpheniramine, and pheniramine to N-oxide and N-demethylated metabolites by the fungus Cunninghamella elegans

Xenobiotica, 1995, Vol.25 (10), p.1081-1092

1995

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Utility of solution electrochemistry mass spectrometry for investigating the formation and detection of biologically important conjugates of acetaminophen

Journal of chromatography, 1989-07, Vol.474 (1), p.245-256

1989

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Systematic LC/MS metabolite identification in drug discovery

Chiral liquid chromatography-tandem mass spectrometric methods for stereoisomeric pharmaceutical determinations

Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice

Rheumatologie im Spiegel der Medien und Werbung am Beispiel des Rheumazentrum Rhein-Ruhr

Rheumatology in the mirror of media and advertising exemplified by the Rheumazentrum Rhein-Ruhr

Quantitative screening and matrix effect studies of drug discovery compounds in monkey plasma using fast-gradient liquid chromatography/tandem mass spectrometry

Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery

Principles and applications of LC-MS in new drug discovery

Matrix-assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue

Direct simultaneous analysis of plasma samples for a drug discovery compound and its hydroxyl metabolite using mixed-function column liquid chromatography-tandem mass spectrometry

Examining the Principles in Principled Conservatism: The Role of Responsibility Stereotypes as Cues for Deservingness in Racial Policy Decisions

HPLC-API/MS/MS: a powerful tool for integrating drug metabolism into the drug discovery process

Microsample Determination of Lovastatin and its Hydroxy Acid Metabolite in Mouse and Rat Plasma by Liquid Chromatography/Ionspray Tandem Mass Spectrometry

Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats

Pharmacokinetic screening for the selection of new drug discovery candidates is greatly enhanced through the use of liquid chromatography–atmospheric pressure ionization tandem mass spectrometry

High-performance liquid chromatography—thermospray mass spectrometry of ten sulfonamide antibiotics: Analysis in milk at the ppb level

Direct analysis of plasma samples for drug discovery compounds using mixed-function column liquid chromatography tandem mass spectrometry

Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry

Investigation of matrix effects in bioanalytical high-performance liquid chromatography/tandem mass spectrometric assays: application to drug discovery

Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice

Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models

The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety

Fungal transformations of antihistamines: metabolism of brompheniramine, chlorpheniramine, and pheniramine to N-oxide and N-demethylated metabolites by the fungus Cunninghamella elegans

Utility of solution electrochemistry mass spectrometry for investigating the formation and detection of biologically important conjugates of acetaminophen

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