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Mitochondria as a therapeutic target for common pathologies

Nature reviews. Drug discovery, 2018-12, Vol.17 (12), p.865-886

2018

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Mitochondria-targeted small molecule therapeutics and probes

Antioxidants & redox signaling, 2011-12, Vol.15 (12), p.3021

2011

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Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon

Redox biology, 2020-09, Vol.36, p.101606-101606, Article 101606

2020

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Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

Cell metabolism, 2011-03, Vol.13 (3), p.340-350

2011

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A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo

Free radical biology & medicine, 2020-02, Vol.147, p.37-47

2020

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Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat

Free radical biology & medicine, 2015-12, Vol.89, p.883-894

2015

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MitoNeoD: A Mitochondria-Targeted Superoxide Probe

Cell chemical biology, 2017-10, Vol.24 (10), p.1285-1298.e12

2017

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Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo

Cell chemical biology, 2019-03, Vol.26 (3), p.449-461.e8

2019

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Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore

Journal of the American Chemical Society, 2012-01, Vol.134 (2), p.758-761

2012

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Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation

Nature metabolism, 2019-09, Vol.1 (10), p.966-974

2019

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A Cell-Permeable Biscyclooctyne As a Novel Probe for the Identification of Protein Sulfenic Acids

ACS chemical biology, 2016-12, Vol.11 (12), p.3300-3304

2016

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Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA

The Journal of biological chemistry, 2017-05, Vol.292 (19), p.7761-7773

2017

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Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury

Redox biology, 2020-09, Vol.36 (C), p.101640-101640, Article 101640

2020

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Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila

Nature protocols, 2012-04, Vol.7 (5), p.946-958

2012

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Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

eLife, 2017-09, Vol.6

2017

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Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury

Redox biology, 2022-09, Vol.55, p.102429-102429, Article 102429

2022

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Using the MitoB method to assess levels of reactive oxygen species in ecological studies of oxidative stress

Scientific reports, 2017-01, Vol.7 (1), p.41228-41228, Article 41228

2017

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Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response

iScience, 2022-02, Vol.25 (2), p.103827-103827, Article 103827

2022

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Bioavailability of [2-14C]Quercetin-4′-glucoside in Rats

Journal of agricultural and food chemistry, 2008-12, Vol.56 (24), p.12127-12137

2008

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Targeting Methylglyoxal in Diabetic Kidney Disease Using the Mitochondria-Targeted Compound MitoGamide

Nutrients, 2021-04, Vol.13 (5), p.1457

2021

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A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes

Free radical biology & medicine, 2014-02, Vol.67 (100), p.437-450

2014

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Mitochondrial pharmacology

Trends in pharmacological sciences (Regular ed.), 2012-06, Vol.33 (6), p.341-352

2012

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A Prototypical Small-Molecule Modulator Uncouples Mitochondria in Response to Endogenous Hydrogen Peroxide Production

Chembiochem : a European journal of chemical biology, 2013-05, Vol.14 (8), p.993-1000

2013

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Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation, and Endoplasmic Reticulum Stress Response in Hypertension

Hypertension (Dallas, Tex. 1979), 2018-07, Vol.72 (1), p.235-246

2018

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Mitochondria as a therapeutic target for common pathologies

Mitochondria-targeted small molecule therapeutics and probes

Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon

Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo

Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat

MitoNeoD: A Mitochondria-Targeted Superoxide Probe

Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo

Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore

Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation

A Cell-Permeable Biscyclooctyne As a Novel Probe for the Identification of Protein Sulfenic Acids

Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA

Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury

Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila

Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury

Using the MitoB method to assess levels of reactive oxygen species in ecological studies of oxidative stress

Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response

Bioavailability of [2-14C]Quercetin-4′-glucoside in Rats

Targeting Methylglyoxal in Diabetic Kidney Disease Using the Mitochondria-Targeted Compound MitoGamide

A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes

Mitochondrial pharmacology

A Prototypical Small-Molecule Modulator Uncouples Mitochondria in Response to Endogenous Hydrogen Peroxide Production

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation, and Endoplasmic Reticulum Stress Response in Hypertension

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