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Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights

Nature reviews. Gastroenterology & hepatology, 2016-06, Vol.13 (6), p.338

2016

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The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

The Journal of biological chemistry, 2020-04, Vol.295 (15), p.4773-4779

2020

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Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template

The Journal of biological chemistry, 2021-07, Vol.297 (1), p.100770-100770, Article 100770

2021

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Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

The Journal of biological chemistry, 2020-05, Vol.295 (20), p.6785-6797

2020

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Zika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress Response

Journal of virology, 2017-08, Vol.91 (16)

2017

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Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action

The Journal of biological chemistry, 2020-11, Vol.295 (47), p.16156-16165

2020

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Pure spin current devices based on ferromagnetic topological insulators

Scientific reports, 2016-10, Vol.6 (1), p.36070-36070, Article 36070

2016

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The active form of the influenza cap-snatching endonuclease inhibitor baloxavir marboxil is a tight binding inhibitor

The Journal of biological chemistry, 2021-01, Vol.296, p.100486-100486, Article 100486

2021

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Conformational Changes Spanning Angstroms to Nanometers via a Combined Protein-Induced Fluorescence Enhancement-Förster Resonance Energy Transfer Method

The journal of physical chemistry. B, 2017-03, Vol.121 (9), p.2039-2048

2017

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Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

Science translational medicine, 2022-08, Vol.14 (656), p.eabo0718

2022

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Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition

Proceedings of the National Academy of Sciences - PNAS, 2022-07, Vol.119 (27), p.1-e2200260119

2022

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Modular Assembly of Purine-like Bisphosphonates as Inhibitors of HIV‑1 Reverse Transcriptase

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7435-7449

2014

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Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases

Proceedings of the National Academy of Sciences - PNAS, 2020-10, Vol.117 (43), p.26946-26954

2020

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Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir

The Journal of biological chemistry, 2022-02, Vol.298 (2), p.101529-101529, Article 101529

2022

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Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (51), p.20509-20513

2011

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Binding Kinetics and Affinities of Heterodimeric versus Homodimeric HIV‑1 Reverse Transcriptase on DNA–DNA Substrates at the Single-Molecule Level

The journal of physical chemistry. B, 2013-04, Vol.117 (16), p.4560-4567

2013

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Delayed Chain Termination Protects the Anti-hepatitis B Virus Drug Entecavir from Excision by HIV-1 Reverse Transcriptase

The Journal of biological chemistry, 2008-12, Vol.283 (49), p.34218-34228

2008

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Binding and Sliding Dynamics of the Hepatitis C Virus Polymerase: Hunting the 3′ Terminus

ACS infectious diseases, 2023-08, Vol.9 (8), p.1488-1498

2023

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Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action

Journal of Virology, 2006-12, Vol.80 (24), p.12283-12292

2006

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Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics

Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (11), p.3475-3480

2015

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Structural basis for substrate selection by the SARS-CoV-2 replicase

Nature (London), 2023-02, Vol.614 (7949), p.781

2023

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Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility

Journal of virology, 2015-04, Vol.89 (8), p.4636-4644

2015

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Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanisms

The Journal of biological chemistry, 2008-08, Vol.283 (32), p.22222-22232

2008

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Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and Viral RNA Show Extensive Overlap

ACS infectious diseases, 2016-11, Vol.2 (11), p.839-851

2016

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Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α‑Carboxy Nucleoside Phosphonates

Journal of medicinal chemistry, 2015-10, Vol.58 (20), p.8110-8127

2015

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Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

Zika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress Response

Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action

Pure spin current devices based on ferromagnetic topological insulators

The active form of the influenza cap-snatching endonuclease inhibitor baloxavir marboxil is a tight binding inhibitor

Conformational Changes Spanning Angstroms to Nanometers via a Combined Protein-Induced Fluorescence Enhancement-Förster Resonance Energy Transfer Method

Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition

Modular Assembly of Purine-like Bisphosphonates as Inhibitors of HIV‑1 Reverse Transcriptase

Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases

Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir

Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance

Binding Kinetics and Affinities of Heterodimeric versus Homodimeric HIV‑1 Reverse Transcriptase on DNA–DNA Substrates at the Single-Molecule Level

Delayed Chain Termination Protects the Anti-hepatitis B Virus Drug Entecavir from Excision by HIV-1 Reverse Transcriptase

Binding and Sliding Dynamics of the Hepatitis C Virus Polymerase: Hunting the 3′ Terminus

Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action

Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics

Structural basis for substrate selection by the SARS-CoV-2 replicase

Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility

Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanisms

Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and Viral RNA Show Extensive Overlap

Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α‑Carboxy Nucleoside Phosphonates

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