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Complex cocktails: the evolutionary novelty of venoms

Trends in ecology & evolution (Amsterdam), 2013-04, Vol.28 (4), p.219-229

2013

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Venom Evolution: Gene Loss Shapes Phenotypic Adaptation

Current biology, 2016-09, Vol.26 (18), p.R849-R851

Casewell, Nicholas R.

2016

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A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

Nature communications, 2020-12, Vol.11 (1), p.6094-14, Article 6094

2020

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An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management

PLoS neglected tropical diseases, 2020-08, Vol.14 (8), p.e0008579

2020

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Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa

PLoS neglected tropical diseases, 2017-10, Vol.11 (10), p.e0005969

2017

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Biogeographic venom variation in Russell's viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots

PLoS neglected tropical diseases, 2021-03, Vol.15 (3), p.e0009247

2021

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Widespread convergence in toxin resistance by predictable molecular evolution

Proceedings of the National Academy of Sciences - PNAS, 2015-09, Vol.112 (38), p.11911-11916

2015

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Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms

Proceedings of the National Academy of Sciences - PNAS, 2014-06, Vol.111 (25), p.9205-9210

2014

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Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy

PLoS neglected tropical diseases, 2021-02, Vol.15 (2), p.e0009150-e0009150

2021

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The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors

Nature communications, 2022-08, Vol.13 (1), p.4543-4543, Article 4543

2022

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A long-term observational study of paediatric snakebite in Kilifi County, south-east Kenya

PLoS neglected tropical diseases, 2023-07, Vol.17 (7), p.e0010987-e0010987

2023

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Clinical outcomes and outcome measurement tools reported in randomised controlled trials of treatment for snakebite envenoming: A systematic review

PLoS neglected tropical diseases, 2021-08, Vol.15 (8), p.e0009589

2021

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Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging

Angewandte Chemie (International ed.), 2020-03, Vol.59 (10), p.3855-3858

International ed. in English, 2020

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High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches

PLoS neglected tropical diseases, 2020-04, Vol.14 (4), p.e0007802-e0007802

2020

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Metabolome-Based Classification of Snake Venoms by Bioinformatic Tools

Toxins, 2023-02, Vol.15 (2), p.161

2023

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Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms

Toxins, 2022-12, Vol.15 (1), p.1

2022

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Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

Nature communications, 2023-12, Vol.14 (1), p.7812-7812, Article 7812

2023

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Exploring the Utility of ssDNA Aptamers Directed against Snake Venom Toxins as New Therapeutics for Snakebite Envenoming

Toxins, 2022-07, Vol.14 (7), p.469

2022

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Next-Generation Sequencing for Venomics: Application of Multi-Enzymatic Limited Digestion for Inventorying the Snake Venom Arsenal

Toxins, 2023-05, Vol.15 (6), p.357

2023

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The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

Toxins, 2021-06, Vol.13 (7), p.451

2021

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Evaluation of the geographical utility of Eastern Russell's viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephrotoxicity

PLoS neglected tropical diseases, 2019-10, Vol.13 (10), p.e0007338

2019

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Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts

BMC genomics, 2009-11, Vol.10 (1), p.564-564

2009

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Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms

PLoS neglected tropical diseases, 2021-08, Vol.15 (8), p.e0009659

2021

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What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus

Biochimica et biophysica acta. General subjects, 2017-04, Vol.1861 (4), p.814-823

2017

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Ending the drought: New strategies for improving the flow of affordable, effective antivenoms in Asia and Africa

Journal of proteomics, 2011-08, Vol.74 (9), p.1735-1767

2011

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Complex cocktails: the evolutionary novelty of venoms

Venom Evolution: Gene Loss Shapes Phenotypic Adaptation

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management

Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa

Biogeographic venom variation in Russell's viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots

Widespread convergence in toxin resistance by predictable molecular evolution

Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms

Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy

The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors

A long-term observational study of paediatric snakebite in Kilifi County, south-east Kenya

Clinical outcomes and outcome measurement tools reported in randomised controlled trials of treatment for snakebite envenoming: A systematic review

Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging

High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches

Metabolome-Based Classification of Snake Venoms by Bioinformatic Tools

Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

Exploring the Utility of ssDNA Aptamers Directed against Snake Venom Toxins as New Therapeutics for Snakebite Envenoming

Next-Generation Sequencing for Venomics: Application of Multi-Enzymatic Limited Digestion for Inventorying the Snake Venom Arsenal

The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

Evaluation of the geographical utility of Eastern Russell's viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephrotoxicity

Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts

Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms

What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus

Ending the drought: New strategies for improving the flow of affordable, effective antivenoms in Asia and Africa

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