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Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients

Nature communications, 2020-02, Vol.11 (1), p.929-929, Article 929

2020

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Tracing tumorigenesis in a solid tumor model at single-cell resolution

Nature communications, 2020-02, Vol.11 (1), p.991-12, Article 991

2020

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The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness

Nature communications, 2020-12, Vol.11 (1), p.6422-15, Article 6422

2020

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Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

Nature communications, 2019-03, Vol.10 (1), p.1444-14, Article 1444

2019

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Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (9), p.3472-3477

2014

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The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis

Nature communications, 2018-08, Vol.9 (1), p.3259-17, Article 3259

2018

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Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors

PloS one, 2024-03, Vol.19 (3), p.e0282938-e0282938

2024

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Continuous Tooth Generation in Mouse Is Induced by Activated Epithelial Wnt/β-Catenin Signaling

Proceedings of the National Academy of Sciences - PNAS, 2006-12, Vol.103 (49), p.18627-18632

2006

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Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice

PloS one, 2021-06, Vol.16 (6), p.e0252649-e0252649

2021

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Wnt/β-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (27), p.10921-10926

2012

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Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (45), p.18174-18179

2013

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Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

Proceedings of the National Academy of Sciences - PNAS, 2008-05, Vol.105 (20), p.7275-7280

2008

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Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence

Nature communications, 2023-08, Vol.14 (1), p.5106-5106, Article 5106

2023

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tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development

Proceedings of the National Academy of Sciences - PNAS, 2009-09, Vol.106 (39), p.16704-16709

2009

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Aberrant Wnt/β-Catenin Signaling Can Induce Chromosomal Instability in Colon Cancer

Proceedings of the National Academy of Sciences - PNAS, 2006-07, Vol.103 (28), p.10747-10752

2006

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Stem cells: Orphan receptors find a home

Nature (London), 2011-08, Vol.476 (7360), p.287

Birchmeier, Walter

2011

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Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo

Proceedings of the National Academy of Sciences - PNAS, 2007-09, Vol.104 (39), p.15376-15381

2007

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Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain

Scientific reports, 2017-08, Vol.7 (1), p.9000-13, Article 9000

2017

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Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice

Genes & development, 2008-09, Vol.22 (17), p.2308-2341

2008

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Diversin Regulates Heart Formation and Gastrulation Movements in Development

Proceedings of the National Academy of Sciences - PNAS, 2006-10, Vol.103 (43), p.15900-15905

2006

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Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

Nature (London), 1996-11, Vol.384 (6605), p.173-176

1996

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Abstract A12: YAP and cancer stem cells in basal-like breast cancer

Molecular cancer research, 2020-08, Vol.18 (8_Supplement), p.A12-A12

2020

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Orphan receptors find a home: the protein Lgr5 has been valuable as the undisputed marker of intestinal and other stem cells. It emerges that Lgr5 and its relatives also have essential signalling roles of relevance to health and disease

Nature (London), 2011-08, Vol.476 (7360), p.287

Birchmeier, Walter

2011

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Orphan receptors find a home

Nature (London), 2011-08, Vol.476 (7360), p.287-288

Birchmeier, Walter

2011

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Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling

Nature (London), 2008-04, Vol.452 (7187), p.650-653

2008

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Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients

Tracing tumorigenesis in a solid tumor model at single-cell resolution

The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis

Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors

Continuous Tooth Generation in Mouse Is Induced by Activated Epithelial Wnt/β-Catenin Signaling

Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice

Wnt/β-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence

tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development

Aberrant Wnt/β-Catenin Signaling Can Induce Chromosomal Instability in Colon Cancer

Stem cells: Orphan receptors find a home

Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo

Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice

Diversin Regulates Heart Formation and Gastrulation Movements in Development

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

Abstract A12: YAP and cancer stem cells in basal-like breast cancer

Orphan receptors find a home: the protein Lgr5 has been valuable as the undisputed marker of intestinal and other stem cells. It emerges that Lgr5 and its relatives also have essential signalling roles of relevance to health and disease

Orphan receptors find a home

Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling

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