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L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Biochemistry (Easton), 2000-08, Vol.39 (30), p.8698-8704

2000

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Gamma-secretase as a therapeutic target for the treatment of Alzheimer's disease

Current pharmaceutical design, 2005-01, Vol.11 (26), p.3363

2005

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Gamma-secretase inhibition

Biochemical Society transactions, 2002-08, Vol.30 (4), p.534

2002

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Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease

Expert opinion on investigational drugs, 2005-11, Vol.14 (11), p.1385-1409

2005

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γ-Secretase Complex Assembly within the Early Secretory Pathway

The Journal of biological chemistry, 2005-02, Vol.280 (8), p.6471-6478

2005

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4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (2), p.280-284

2006

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Generation of C‐terminally truncated amyloid‐β peptides is dependent on γ‐secretase activity

Journal of neurochemistry, 2002-08, Vol.82 (3), p.563-575

2002

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Cyclic sulfamide γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (19), p.4212-4216

2005

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Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2275-2278

2003

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In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand

Biochemistry (Easton), 2003-07, Vol.42 (27), p.8133-8142

2003

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Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

The Journal of biological chemistry, 2001-11, Vol.276 (48), p.45394-45402

2001

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Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity

The Journal of biological chemistry, 2005-04, Vol.280 (13), p.12523-12535

2005

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A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (2), p.373-378

2005

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gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta

The Journal of biological chemistry, 2003-04, Vol.278 (15), p.13077-13085

2003

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gamma-Secretase as a target for drug intervention in Alzheimer's disease

Current opinion in drug discovery & development, 2004-09, Vol.7 (5), p.709

2004

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3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3839-3842

2006

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L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Gamma-secretase as a therapeutic target for the treatment of Alzheimer's disease

Gamma-secretase inhibition

Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease

γ-Secretase Complex Assembly within the Early Secretory Pathway

4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

Generation of C‐terminally truncated amyloid‐β peptides is dependent on γ‐secretase activity

Cyclic sulfamide γ-secretase inhibitors

Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement

In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity

A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core

gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta

gamma-Secretase as a target for drug intervention in Alzheimer's disease

3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity

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