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Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders

Molecular and cellular neuroscience, 2004-01, Vol.25 (1), p.42-55

2004

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L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Biochemistry (Easton), 2000-08, Vol.39 (30), p.8698-8704

2000

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Gamma-secretase as a therapeutic target for the treatment of Alzheimer's disease

Current pharmaceutical design, 2005-01, Vol.11 (26), p.3363

2005

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Determination of guinea-pig cortical γ-secretase activity ex vivo following the systemic administration of a γ-secretase inhibitor

Neuropharmacology, 2005-06, Vol.48 (7), p.1002-1011

2005

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Gamma-secretase inhibition

Biochemical Society transactions, 2002-08, Vol.30 (4), p.534

2002

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Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism

The Journal of biological chemistry, 2004-10, Vol.279 (42), p.43419-43426

2004

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Homodimerization of Amyloid Precursor Protein and Its Implication in the Amyloidogenic Pathway of Alzheimer's Disease

The Journal of biological chemistry, 2001-09, Vol.276 (36), p.33923-33929

2001

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Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease

Expert opinion on investigational drugs, 2005-11, Vol.14 (11), p.1385-1409

2005

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γ-Secretase Complex Assembly within the Early Secretory Pathway

The Journal of biological chemistry, 2005-02, Vol.280 (8), p.6471-6478

2005

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Generation of C‐terminally truncated amyloid‐β peptides is dependent on γ‐secretase activity

Journal of neurochemistry, 2002-08, Vol.82 (3), p.563-575

2002

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Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2275-2278

2003

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In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand

Biochemistry (Easton), 2003-07, Vol.42 (27), p.8133-8142

2003

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Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

The Journal of biological chemistry, 2001-11, Vol.276 (48), p.45394-45402

2001

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The Intramembrane Cleavage Site of the Amyloid Precursor Protein Depends on the Length of Its Transmembrane Domain

Proceedings of the National Academy of Sciences - PNAS, 2002-02, Vol.99 (3), p.1365-1370

2002

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The βA4 amyloid precursor protein binding to copper

FEBS letters, 1994-07, Vol.349 (1), p.109-116

1994

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Regulation of Amyloid Protein Precursor (APP) Binding to Collagen and Mapping of the Binding Sites on APP and Collagen Type I (∗)

The Journal of biological chemistry, 1996-01, Vol.271 (3), p.1613-1620

1996

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Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells

Journal of lipid research, 2004-12, Vol.45 (12), p.2368-2376

2004

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Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity

The Journal of biological chemistry, 2005-04, Vol.280 (13), p.12523-12535

2005

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Regulation of APP Expression, Biogenesis and Metabolism by Extracellular Matrix and Cytokines

Annals of the New York Academy of Sciences, 1996-01, Vol.777 (1), p.74-76

1996

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gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta

The Journal of biological chemistry, 2003-04, Vol.278 (15), p.13077-13085

2003

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Regulation of APP Expression, Biogenesis and Metabolism by Extracellular Matrix and Cytokinesa

Annals of the New York Academy of Sciences, 1996-01, Vol.777 (1), p.74-76

1996

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Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and [gamma]-secretase activity

Journal of neurochemistry, 2005-09, Vol.94 (5), p.1315

2005

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425 Alternative splicing of exon 15 regulates APP conformation

Neurobiology of aging, 1996, Vol.17 (4), p.S106-S106

1996

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gamma-Secretase as a target for drug intervention in Alzheimer's disease

Current opinion in drug discovery & development, 2004-09, Vol.7 (5), p.709

2004

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426 APP shares glycan modifications characteristic of cell adhesion molecules

Neurobiology of aging, 1996, Vol.17 (4), p.S106-S106

1996

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Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders

L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Gamma-secretase as a therapeutic target for the treatment of Alzheimer's disease

Determination of guinea-pig cortical γ-secretase activity ex vivo following the systemic administration of a γ-secretase inhibitor

Gamma-secretase inhibition

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism

Homodimerization of Amyloid Precursor Protein and Its Implication in the Amyloidogenic Pathway of Alzheimer's Disease

Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease

γ-Secretase Complex Assembly within the Early Secretory Pathway

Generation of C‐terminally truncated amyloid‐β peptides is dependent on γ‐secretase activity

Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement

In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

The Intramembrane Cleavage Site of the Amyloid Precursor Protein Depends on the Length of Its Transmembrane Domain

The βA4 amyloid precursor protein binding to copper

Regulation of Amyloid Protein Precursor (APP) Binding to Collagen and Mapping of the Binding Sites on APP and Collagen Type I (∗)

Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells

Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity

Regulation of APP Expression, Biogenesis and Metabolism by Extracellular Matrix and Cytokines

gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta

Regulation of APP Expression, Biogenesis and Metabolism by Extracellular Matrix and Cytokinesa

Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and [gamma]-secretase activity

425 Alternative splicing of exon 15 regulates APP conformation

gamma-Secretase as a target for drug intervention in Alzheimer's disease

426 APP shares glycan modifications characteristic of cell adhesion molecules

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